IFNAR1 Rabbit Monoclonal Antibody

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SKU:
CAB0575
€129 - €349

Description

Technical Manual

IFNAR1 Rabbit Monoclonal Antibody

Product Name:IFNAR1 Rabbit Monoclonal Antibody
Product SKU:CAB0575
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human IFNAR1
Sequence:

Email for sequence

Gene ID:3454
Swiss Prot:P17181
Synonyms:AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
Calculated MW:90, 130kDa
Observed MW:90-130KDa
Reactivity:Human, Mouse, Rat
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:HepG2, A-549, NIH/3T3, Mouse brain, Rat lung, Rat liver
Cellular Location:

Product Images

IFNAR1 Rabbit Monoclonal Antibody

Western blot - IFNAR1 Rabbit mAb (CAB0575)

Uniprot Information

UniProt Protein Function:IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.
UniProt Protein Details:

Protein type:Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function:protein binding; interferon receptor activity; interferon-alpha/beta receptor activity

Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; cytokine and chemokine mediated signaling pathway; response to virus; positive regulation of interleukin-1 beta secretion; interferon type I biosynthetic process; JAK-STAT cascade; defense response to virus

NCBI Summary:The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
UniProt Code:P17181
NCBI GenInfo Identifier:90110827
NCBI Gene ID:3454
NCBI Accession:P17181.3
UniProt Secondary Accession:P17181,Q53GW9, Q53H11, Q6PKD7, Q7M4L2, Q8WTZ2, B2R6L9 B4DNT3, D3DSF0,
UniProt Related Accession:P17181
Molecular Weight:Calculated MW: 49kDa/56kDa/63kDaObserved MW: 70kDa
NCBI Full Name:Interferon alpha/beta receptor 1
NCBI Synonym Full Names:interferon (alpha, beta and omega) receptor 1
NCBI Official Symbol:IFNAR1 
NCBI Official Synonym Symbols:AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC 
NCBI Protein Information:interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain
UniProt Protein Name:Interferon alpha/beta receptor 1
UniProt Synonym Protein Names:Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1
Protein Family:Interferon alpha/beta receptor
UniProt Gene Name:IFNAR1 
UniProt Entry Name:INAR1_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
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