JNK3 Rabbit Monoclonal Antibody (CAB19075)

(No reviews yet) Write a Review
SKU:
CAB19075
€129 - €349

Description

Technical Manual

JNK3 Rabbit Monoclonal Antibody

Product Name:JNK3 Rabbit Monoclonal Antibody
Product SKU:CAB19075
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]

Immunogen:A synthesized peptide derived from human JNK3
Sequence:

Email for sequence

Gene ID:5602
Swiss Prot:P53779
Synonyms:JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK10
Calculated MW:53kDa
Observed MW:53kDa
Reactivity:Human, Mouse, Rat
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:MCF7, Mouse brain, Mouse testis, Rat brain, Rat testis
Cellular Location:

Product Images

JNK3 Rabbit Monoclonal Antibody (CAB19075)

Western blot - JNK3 Rabbit mAb (CAB19075)

Uniprot Information

UniProt Protein Function:Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).
NCBI Summary:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
UniProt Code:P53779
NCBI GenInfo Identifier:2507196
NCBI Gene ID:5602
NCBI Accession:P53779.2
UniProt Secondary Accession:P53779,Q15707, Q49AP1, A6NFS3, A6NG28, B3KQ94,
UniProt Related Accession:P53779
Molecular Weight:31,933 Da
NCBI Full Name:Mitogen-activated protein kinase 10
NCBI Synonym Full Names:mitogen-activated protein kinase 10
NCBI Official Symbol:MAPK10 
NCBI Official Synonym Symbols:JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK 
NCBI Protein Information:mitogen-activated protein kinase 10
UniProt Protein Name:Mitogen-activated protein kinase 10
UniProt Synonym Protein Names:MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3
UniProt Gene Name:MAPK10 
UniProt Entry Name:MK10_HUMAN
View AllClose

Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
View AllClose

0 Reviews

View AllClose