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Anti-LAMP2 Antibody (CAB1961)

SKU:
CAB1961
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Autophagy
  • Autophagy Antibodies Anti-LAMP2 Antibody CAB1961
  • Autophagy Antibodies Anti-LAMP2 Antibody CAB1961
  • Autophagy Antibodies Anti-LAMP2 Antibody CAB1961
€139 - €419
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Description

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Antibody Name:Anti-LAMP2 Antibody
Antibody SKU:CAB1961
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human LAMP2 (NP_054701.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:MCF7, U-937
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human LAMP2 (NP_054701.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ELNL TDSE NATC LYAK WQMN FTVR YETT NKTY KTVT ISDH GTVT YNGS ICGD DQNG PKIA VQFG PGFS WIAN FTKA ASTY SIDS VSFS YNTG DNTT FPDA EDKG ILTV DELL AIRI PLND LFRC NSLS TLEK NDVV QHYW DVLV QAFV QNGT VSTN EFLC DKDK TSTV APTI HTTV PSPT TTPT PKEK PEAG TYSV NNGN DTCL LATM GLQL NITQ DKVA SVIN INPN TTHS TGSC RSHT ALLR LNSS TIKY LDFV FAVK NENR FYLK EVN
Gene ID:3920
Uniprot:P13473
Cellular Location:Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein
Calculated MW:44kDa/45kDa
Observed MW:118kDa
Synonyms:LAMP2, CD107b, LAMP-2, LAMPB, LGP-96, LGP110
Background:The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins.
UniProt Protein Function:LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: phagocytic vesicle membrane; membrane; lysosome; lysosomal membrane; late endosome membrane; late endosome; plasma membrane; integral to membrane; platelet dense granule membrane

Molecular Function:protein domain specific binding; enzyme binding

Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation

Disease: Danon Disease

NCBI Summary:The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
UniProt Code:P13473
NCBI GenInfo Identifier:1708854
NCBI Gene ID:3920
NCBI Accession:P13473.2
UniProt Secondary Accession:P13473,Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93, A8K4X5 D3DTF0,
UniProt Related Accession:P13473
Molecular Weight:410
NCBI Full Name:Lysosome-associated membrane glycoprotein 2
NCBI Synonym Full Names:lysosomal-associated membrane protein 2
NCBI Official Symbol:LAMP2  
NCBI Official Synonym Symbols:LAMPB; CD107b; LAMP-2; LGP110  
NCBI Protein Information:lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B
UniProt Protein Name:Lysosome-associated membrane glycoprotein 2
UniProt Synonym Protein Names:CD107 antigen-like family member B; CD_antigen: CD107b
Protein Family:Lysosome-associated membrane glycoprotein
UniProt Gene Name:LAMP2  
UniProt Entry Name:LAMP2_HUMAN
Anti-LAMP2 Antibody (CAB1961)Western blot analysis of extracts of various cell lines, using LAMP2 antibody (CAB1961) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-LAMP2 Antibody (CAB1961)Immunohistochemistry of paraffin-embedded human breast cancer using LAMP2 Antibody (CAB1961) at dilution of 1:100 (40x lens).
Anti-LAMP2 Antibody (CAB1961)Immunohistochemistry of paraffin-embedded human gastric cancer using LAMP2 Antibody (CAB1961) at dilution of 1:100 (40x lens).

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