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Anti-Mannose Receptor/CD206 Antibody (CAB11192)

SKU:
CAB11192
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Mannose Receptor/CD206 Antibody
Antibody SKU:CAB11192
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Mannose Receptor/CD206
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Raji, Mouse lung
Immunogen:A synthesized peptide derived from human Mannose Receptor/CD206
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4360
Uniprot:P22897
Cellular Location:
Calculated MW:166kDa
Observed MW:166KDa
Anti-Mannose Receptor/CD206 AntibodyWestern blot - Mannose Receptor/CD206 Rabbit mAb (CAB11192)
Synonyms:CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR
Background:The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
UniProt Protein Function:MRC1: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 10p12.33

Cellular Component: endosome membrane; integral to plasma membrane; plasma membrane

Molecular Function:protein binding; receptor activity; transmembrane receptor activity

Biological Process: receptor-mediated endocytosis

NCBI Summary:The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
UniProt Code:P22897
NCBI GenInfo Identifier:126730
NCBI Gene ID:4360
NCBI Accession:P22897.1
UniProt Secondary Accession:P22897,Q5VSJ2, Q5VSK2, A5PKW3,
UniProt Related Accession:P22897
Molecular Weight:166kDa
NCBI Full Name:Macrophage mannose receptor 1
NCBI Synonym Full Names:mannose receptor C-type 1
NCBI Official Symbol:MRC1  
NCBI Official Synonym Symbols:MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1  
NCBI Protein Information:macrophage mannose receptor 1
UniProt Protein Name:Macrophage mannose receptor 1
UniProt Synonym Protein Names:C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Human mannose receptor; hMR; Macrophage mannose receptor 1-like protein 1; CD_antigen: CD206
Protein Family:Macrophage mannose receptor
UniProt Gene Name:MRC1  

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