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Anti-MEF2A Antibody (CAB7911)

SKU:
CAB7911
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 2 Anti-MEF2A Antibody CAB7911
  • Cell Death Antibodies 2 Anti-MEF2A Antibody CAB7911
€139 - €419
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Description

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Antibody Name:Anti-MEF2A Antibody
Antibody SKU:CAB7911
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human MEF2A
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:SW480, Mouse skeletal muscle
Immunogen:A synthetic peptide of human MEF2A
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4205
Uniprot:Q02078
Cellular Location:Nucleus
Calculated MW:45kDa/46kDa/53kDa/54kDa
Observed MW:55kDa
Synonyms:MEF2A, ADCAD1, RSRFC4, RSRFC9, mef2
Background:The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:MEF2A: a myocyte-specific enhancing transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many, if not all, muscle-specific genes. A member of the MADS gene family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. Five alternatively spliced isoforms have been reported.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function:chromatin binding; histone acetyltransferase binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; SMAD binding; transcription activator binding; transcription factor activity

Biological Process: apoptosis; dendrite morphogenesis; heart development; innate immune response; MAPKKK cascade; mitochondrial genome maintenance; mitochondrion distribution; muscle cell differentiation; muscle development; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter; transcription, DNA-dependent; ventricular cardiac myofibril development

Disease: Coronary Artery Disease, Autosomal Dominant, 1

NCBI Summary:The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
UniProt Code:Q02078
NCBI GenInfo Identifier:1170908
NCBI Gene ID:4205
NCBI Accession:Q02078.1
UniProt Secondary Accession:Q02078,O43814, Q14223, Q14224, Q59GX4, Q7Z6C9, Q96D14 B4DFQ7, F6XG23,
UniProt Related Accession:Q02078
Molecular Weight:45,570 Da
NCBI Full Name:Myocyte-specific enhancer factor 2A
NCBI Synonym Full Names:myocyte enhancer factor 2A
NCBI Official Symbol:MEF2A  
NCBI Official Synonym Symbols:mef2; ADCAD1; RSRFC4; RSRFC9  
NCBI Protein Information:myocyte-specific enhancer factor 2A
UniProt Protein Name:Myocyte-specific enhancer factor 2A
UniProt Synonym Protein Names:Serum response factor-like protein 1
Protein Family:Myocyte-specific enhancer factor
UniProt Gene Name:MEF2A  
UniProt Entry Name:MEF2A_HUMAN
Anti-MEF2A Antibody (CAB7911)Western blot analysis of extracts of various cell lines, using MEF2A antibody (CAB7911) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-MEF2A Antibody (CAB7911)Immunofluorescence analysis of U2OS cells using MEF2A antibody (CAB7911) at dilution of 1:100. Blue: DAPI for nuclear staining.

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