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Anti-Myelin oligodendrocyte glycoprotein Antibody (CAB3992)

SKU:
CAB3992
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Myelin oligodendrocyte glycoprotein Antibody
Antibody SKU:CAB3992
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Myelin oligodendrocyte glycoprotein
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human Myelin oligodendrocyte glycoprotein
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4340
Uniprot:Q16653
Cellular Location:
Calculated MW:28kDa
Observed MW:28KDa
Synonyms:BTN6, BTNL11, MOGIG2, NRCLP7
Background:The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Protein Function:MOG: Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7). Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Belongs to the immunoglobulin superfamily. BTN/MOG family. 10 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: integral to membrane; plasma membrane

Biological Process: central nervous system development; positive regulation of MyD88-dependent toll-like receptor signaling pathway; cell adhesion

Disease: Narcolepsy 7

NCBI Summary:The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q16653
NCBI GenInfo Identifier:317373391
NCBI Gene ID:4340
NCBI Accession:Q16653.2
UniProt Secondary Accession:Q16653,O00713, O00714, O00715, Q13054, Q13055, A6NDR4 A6NNJ9, A8MY31, B0UZR9, E9PGF0, F8W9D5,
UniProt Related Accession:Q16653
Molecular Weight:247
NCBI Full Name:Myelin-oligodendrocyte glycoprotein
NCBI Synonym Full Names:myelin oligodendrocyte glycoprotein
NCBI Official Symbol:MOG  
NCBI Official Synonym Symbols:BTN6; BTNL11; MOGIG2; NRCLP7  
NCBI Protein Information:myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5
UniProt Protein Name:Myelin-oligodendrocyte glycoprotein
Protein Family:Molybdopterin adenylyltransferase
UniProt Gene Name:MOG  
UniProt Entry Name:MOG_HUMAN
Anti-Myelin oligodendrocyte glycoprotein Antibody (CAB3992)Western blot - Myelin oligodendrocyte glycoprotein Rabbit mAb (CAB3992)

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