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Purified Anti-Mouse CD122 Antibody [5H4] (AGEL0144)

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SKU AGEL0144
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgG2a
Clone 5H4
Conjugation Unconjugated
Applications FC
Applications IP
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Description

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Purified Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody (5H4) is a specialized antibody designed for research applications involving CD122, a key cell surface receptor associated with immune system function. This monoclonal antibody is produced specifically for use in mouse samples and is validated for various experimental techniques, including Western blotting and flow cytometry.CD122, also known as the interleukin-2 receptor beta chain, is integral to the signaling pathways involved in immune response regulation and T cell activation. By targeting CD122, researchers can gain insights into the mechanisms underlying immune system modulation and its implications in various diseases, such as autoimmunity, infections, and cancer.

The Mouse CD122 Monoclonal Antibody (5H4) facilitates the detection and analysis of CD122 protein expression in mouse cell populations, providing a valuable tool for immunological studies and therapeutic research. Its high specificity and sensitivity make it an essential component in investigating the functions and interactions of CD122 in the context of immune responses and related disorders.

Product Title:Purified Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0144
Size:25µg, 100µg
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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