Mouse CD80 Recombinant Protein (RPPB3030)
- SKU:
- RPPB3030
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q00609
- Research Area:
- CD Antigens
Description
| Product Name: | Mouse CD80 Recombinant Protein |
| Product Code: | RPPB3030 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | CD80 |
| Synonyms: | LAB7,CD28LG, CD28LG1, CD28LG1, B71. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD80 protein solution (0.25mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | DVDEQLSKSV KDKVLLPCRY NSPHEDESED RIYWQKHDKV VLSVIAGKLKVWPEYKNRTL YDNTTYSLII LGLVLSDRGT YSCVVQKKER GTYEVKHLAL VKLSIKADFS TPNITESGNPSADTKRITCF ASGGFPKPRF SWLENGRELP GINTTISQDP ESELYTISSQ LDFNTTRNHT IKCLIKYGDAHVSEDFTWEK PPEDPPDSKN HHHHHH |
The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells CD-80 is involved in the costimulatory signal essential for t- lymphocyte activation. t-cell proliferation and cytokine production is induced by the binding of cd28 or ctla-4 to this receptor.
CD80 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 216 amino acids (37-246 a.a.) andhaving a molecular mass of 24.7kDa (Migrates at 28-40kDa on SDS-PAGE underreducing conditions).CD80 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD80: Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Immunoglobulin superfamily Cellular Component: cell surface; membrane; integral to membrane; external side of plasma membrane Molecular Function:protein binding Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; T cell costimulation; positive regulation of alpha-beta T cell proliferation; positive regulation of T cell proliferation |
| UniProt Code: | Q00609 |
| NCBI GenInfo Identifier: | 461607 |
| NCBI Gene ID: | 12519 |
| NCBI Accession: | Q00609.1 |
| UniProt Secondary Accession: | Q00609,Q61332, |
| UniProt Related Accession: | Q00609 |
| Molecular Weight: | 24,051 Da |
| NCBI Full Name: | T-lymphocyte activation antigen CD80 |
| NCBI Synonym Full Names: | CD80 antigen |
| NCBI Official Symbol: | Cd80�� |
| NCBI Official Synonym Symbols: | B71; Ly53; TSA1; Cd28l; Ly-53; MIC17�� |
| NCBI Protein Information: | T-lymphocyte activation antigen CD80; B7 protein; activation B7-1 antigen |
| UniProt Protein Name: | T-lymphocyte activation antigen CD80 |
| UniProt Synonym Protein Names: | Activation B7-1 antigen; B7; CD_antigen: CD80 |
| Protein Family: | T-lymphocyte activation antigen |
| UniProt Gene Name: | Cd80�� |
| UniProt Entry Name: | CD80_MOUSE |
