Description

Purified Anti-Mouse CD86 Antibody [GL-1]

The Mouse CD86 Monoclonal Antibody (GL-1) is designed for research involving CD86, a key cell surface molecule critical for immune response modulation and costimulatory signaling. This monoclonal antibody, produced in mice, is highly specific to mouse CD86 and is validated for use in flow cytometry and immunohistochemistry applications. It binds to the CD86 protein, enabling precise detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.CD86, also known as B7-2, plays a crucial role in the activation of T cells and the modulation of immune responses by interacting with CD28 and CTLA-4 receptors. Its importance in immune regulation makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

The Mouse CD86 Monoclonal Antibody (GL-1) is an indispensable tool for researchers aiming to understand the mechanisms of immune activation and develop therapies that either enhance or suppress immune function.By providing accurate and reliable detection of CD86, this antibody supports comprehensive studies of immune pathways, contributing to the advancement of immunotherapy and the development of innovative treatments for immune-related diseases. Understanding the activity of CD86 is crucial for creating targeted therapies that harness or modulate immune function, making this antibody a critical asset for advancing research in immunology and cancer.

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Product Title:	Purified Anti-Mouse CD86 Antibody [GL-1]
SKU:	AGEL0039
Size:	25µg, 100µg
Clone No:	GL-1
Synonyms:	T-lymphocyte activation antigen CD86;Cd86;Activation B7-2 antigen;Early T-cell costimulatory molecule 1;ETC-1;
Host Species:	Rat
Reactivity:	Mouse
Application:	FCM

Isotype:	Rat IgG2a, κ
Isotype Control:	Purified Rat IgG2a, κ Isotype Control[2A3]
Form:	Liquid
Conjugation:	Unconjugated
Recommended Use:	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Swissprot:	P42082
Gene ID:	12524
Storage Buffer:	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:	CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Purified Anti-Mouse CD86 Antibody [GL-1] (AGEL0039)

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Description