Mouse Eotaxin Recombinant Protein (RPPB1124)
- SKU:
- RPPB1124
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P48298
- Research Area:
- Chemokines
Description
| Product Name: | Mouse Eotaxin Recombinant Protein |
| Product Code: | RPPB1124 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | Eotaxin |
| Synonyms: | Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Eotaxin in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Eotaxin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL11 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be His-Pro-Gly-Ser-Ile |
| Biological Activity: | The Biological activity was determined by measuring the dose dependent phosphorylation of ERK1 and ERK2 in CCR3 transfected 293 cells. Significant ERK phosphorylation is observed with >100 ng/ml (corresponding to a Specific Activity of 10,000IU/mg) of recombinant mouse eotaxin. |
Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.
Eotaxin Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8403.2 Dalton. The CCL11 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Cellular Component: extracellular space; extracellular region; intracellular Molecular Function:chemokine activity; cytokine activity Biological Process: regulation of cell shape; positive regulation of angiogenesis; positive regulation of actin filament polymerization; mast cell chemotaxis; eosinophil chemotaxis; actin filament organization; immune response; positive regulation of endothelial cell proliferation; cytoskeleton organization and biogenesis; chemotaxis; inflammatory response; positive regulation of cell migration |
| UniProt Code: | P48298 |
| NCBI GenInfo Identifier: | 1352377 |
| NCBI Gene ID: | 20292 |
| NCBI Accession: | P48298.1 |
| UniProt Related Accession: | P48298 |
| Molecular Weight: | 10,893 Da |
| NCBI Full Name: | Eotaxin |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 11 |
| NCBI Official Symbol: | Ccl11�� |
| NCBI Official Synonym Symbols: | Scya11; eotaxin�� |
| NCBI Protein Information: | eotaxin; C-C motif chemokine 11; small inducible cytokine A11; small-inducible cytokine A11; eosinophil chemotactic protein; small chemokine (C-C motif) ligand 11 |
| UniProt Protein Name: | Eotaxin |
| UniProt Synonym Protein Names: | C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11 |
| Protein Family: | Eotaxin |
| UniProt Gene Name: | Ccl11�� |
| UniProt Entry Name: | CCL11_MOUSE |
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