Mouse FGF17 Recombinant Protein (RPPB0233)
- SKU:
- RPPB0233
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- O60258
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Mouse FGF17 Recombinant Protein |
| Product Code: | RPPB0233 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | FGF17 |
| Synonyms: | Fibroblast growth factor 17, FGF-17, FGF17, FGF-13, HH20. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2?m filtered concentrated solution in 20 mM Tris-HCl, pH 8.0, ��0.02 % Tween-20 and 700 mM NaCl. |
| Solubility: | It is recommended to reconstitute the lyophilized Fibroblast Growth Factor 17 in sterile PBS not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized FGF17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Fibroblast Growth Factor 17 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | TQGENHPSPN FNQYVRDQGA MTDQLSRRQI REYQLYSRTS GKHVQVTGRR ISATAEDGNK FAKLIVETDT FGSRVRIKGA ESEKYICMNK RGKLIGKPSG KSKDCVFTEI VLENNYTAFQ NARHEGWFMA FTRQGRPRQA SRSRQNQREA HFIKRLYQGQ LPFPNHAERQ KQFEFVGSAP TRRTKRTRRP QSQT |
| Biological Activity: | The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is < 10 ng/ml, corresponding to a specific activity of > 1.0 � 105 IU/mg in the presence of 10 ?g/ml of heparin. |
Fibroblast Growth Factor 17 (FGF17) is a part of the fibroblast growth factor family. FGF family members have broad mitogenic and cell survival activities, and are involved in various biological processes includingmorphogenesis, embryonic development cell growth, , tissue repair, tumor growth and invasion. The FGF17 gene is highly expressed in the cerebellum and cortex. The mouse homolog of the FGF17 gene is localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, suggesting a part in central nervous system, bone and vascular development.
Fibroblast Growth Factor 17 Mouse Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 194 amino acid and having a molecular mass of approximately 22.5kDa.FGF17 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FGF17: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 8p21 Cellular Component: extracellular region; extracellular space Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; nervous system development; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; signal transduction Disease: Hypogonadotropic Hypogonadism 20 With Or Without Anosmia |
| NCBI Summary: | This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
| UniProt Code: | O60258 |
| NCBI GenInfo Identifier: | 6015147 |
| NCBI Gene ID: | 8822 |
| NCBI Accession: | O60258.1 |
| UniProt Secondary Accession: | O60258,Q2M2W1, B7ZLG4, |
| UniProt Related Accession: | O60258 |
| Molecular Weight: | 23,669 Da |
| NCBI Full Name: | Fibroblast growth factor 17 |
| NCBI Synonym Full Names: | fibroblast growth factor 17 |
| NCBI Official Symbol: | FGF17�� |
| NCBI Official Synonym Symbols: | HH20; FGF-13; FGF-17�� |
| NCBI Protein Information: | fibroblast growth factor 17 |
| UniProt Protein Name: | Fibroblast growth factor 17 |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF17�� |
| UniProt Entry Name: | FGF17_HUMAN |
