Mouse Flt3 Ligand Recombinant Protein (RPPB0260)
- SKU:
- RPPB0260
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P49772
- Research Area:
- Cytokines
Description
| Product Name: | Mouse Flt3 Ligand Recombinant Protein |
| Product Code: | RPPB0260 |
| Size: | 5µg |
| Species: | Mouse |
| Target: | Flt3 Ligand |
| Synonyms: | Fms-related tyrosine kinase 3 ligand, Flt3 ligand, Flt3L, SL cytokine, lt3lgF, Flt3l. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | Flt3 Ligand protein solution (0.5mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | GTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR PRQHHHHHH |
FLT3 ligand is a receptor for the fl cytokine has a tyrosine-protein kinase activity & a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand synergizes with other CSFs and interleukins to induce growth and differentiation.
Flt3 Ligand produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (27-189 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 169 amino acids and having a molecular mass of 19.3kDa.Flt3 Ligand shows multiple bands between 18-28kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Ligand, receptor tyrosine kinase; Cytokine Cellular Component: extracellular space; cell surface; membrane; plasma membrane; extracellular region; integral to membrane Molecular Function:protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding Biological Process: positive regulation of natural killer cell differentiation; regulation of myeloid dendritic cell activation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of myoblast differentiation |
| UniProt Code: | P49772 |
| NCBI GenInfo Identifier: | 1706819 |
| NCBI Gene ID: | 14256 |
| NCBI Accession: | P49772.1 |
| UniProt Secondary Accession: | P49772,Q64085, |
| UniProt Related Accession: | P49772 |
| Molecular Weight: | 28,259 Da |
| NCBI Full Name: | Fms-related tyrosine kinase 3 ligand |
| NCBI Synonym Full Names: | FMS-like tyrosine kinase 3 ligand |
| NCBI Official Symbol: | Flt3l�� |
| NCBI Official Synonym Symbols: | Ly72L; Flt3lg�� |
| NCBI Protein Information: | fms-related tyrosine kinase 3 ligand; flt3 ligand |
| UniProt Protein Name: | Fms-related tyrosine kinase 3 ligand |
| UniProt Synonym Protein Names: | SL cytokine |
| Protein Family: | Receptor-type tyrosine-protein kinase |
| UniProt Gene Name: | Flt3lg�� |
| UniProt Entry Name: | FLT3L_MOUSE |
