Mouse GDF15 Recombinant Protein (RPPB0315)
- SKU:
- RPPB0315
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q9Z0J7
- Research Area:
- Cytokines
Description
| Product Name: | Mouse GDF15 Recombinant Protein |
| Product Code: | RPPB0315 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | GDF15 |
| Synonyms: | Growth/differentiation factor 15, GDF-15. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | GDF15 protein solution (1.0mg/ml) containing 20mMPhosphate buffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSAHAHPR DSCPLGPGRC CHLETVQATL EDLGWSDWVL SPRQLQLSMCVGECPHLYRS ANTHAQIKAR LHGLQPDKVP APCCVPSSYT PVVLMHRTDS GVSLQTYDDL VARGCHCA |
GDF15 is part of the TGF-Beta superfamily which is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance.
GDF15 Mouse Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 138 amino acids (189-303 a.a) and having amolecular mass of 14.9kDa.GDF15 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GDF15: disulfide-linked. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Cellular Component: extracellular space; extracellular region Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding Biological Process: regulation of apoptosis; regulation of MAPKKK cascade; cell development |
| UniProt Code: | Q9Z0J7 |
| NCBI GenInfo Identifier: | 408360114 |
| NCBI Gene ID: | 23886 |
| NCBI Accession: | Q9Z0J7.2 |
| UniProt Secondary Accession: | Q9Z0J7,Q6NX63, |
| UniProt Related Accession: | Q9Z0J7 |
| Molecular Weight: | 33,225 Da |
| NCBI Full Name: | Growth/differentiation factor 15 |
| NCBI Synonym Full Names: | growth differentiation factor 15 |
| NCBI Official Symbol: | Gdf15�� |
| NCBI Official Synonym Symbols: | SBF; MIC-1; NAG-1�� |
| NCBI Protein Information: | growth/differentiation factor 15; GDF-15; macrophage inhibiting cytokine-1 |
| UniProt Protein Name: | Growth/differentiation factor 15 |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | Gdf15�� |
| UniProt Entry Name: | GDF15_MOUSE |
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