Mouse IL31 Recombinant Protein (RPPB0658)
- Product Type:
- Recombinant Protein
- Research Area:
|Mouse IL31 Recombinant Protein
|Interleukin 31, IL31, IL-31.
|Sterile Filtered White lyophilized (freeze-dried) powder.
|The IL31 (1mg/ml) was lyophilized from 10mM sodium Phosphate pH-7.5.
|It is recommended to reconstitute the lyophilized IL31 in sterile 18M? -cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
|Lyophilized IL31 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL31 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
|Greater than 95.0% as determined by SDS-PAGE.
|Amino Acid Sequence:
|MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C
IL-31 produced by activated Th2-type T cells, cooperates with a heterodimeric receptor consisting of IL-31 Receptor Anatagonist and Onconstatin-M Receptor that is continuesly expressed on epithelial cells and keratinocytes. IL-31 plays a role in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma. IL-31 is involved in the itching sensation and endorses the scratching behavior in NC/Nga mice with atopic dermatitis. IL-31 expression is connectd with CLA(+) T cells and contributes to the development of atopic dermatitis-induced skin inflammation and pruritus. IL-31 is a powerful inducer of proinflammatory mediators in human colonic SEMFs. IL-31 takes part as a proinflammatory cytokine derived from Th2 cells.Serum IL-31 level is higher in patients with atopic dermatitis. IL-31 is involved in a broad range of immune- & non-immune cells & possesses potential pleiotropic physiological functions, including regulating hematopoiesis & immune re
IL31 mouse recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids and having a molecular mass of 15.7 kDa.
|UniProt Protein Function:
|IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunityProtein type: Cytokine; Secreted, signal peptide; SecretedCellular Component: extracellular space; extracellular regionMolecular Function: cytokine activityBiological Process: immune system process
|UniProt Protein Details:
|NCBI GenInfo Identifier:
|NCBI Gene ID:
|UniProt Secondary Accession:
|UniProt Related Accession:
|NCBI Full Name:
|NCBI Synonym Full Names:
|NCBI Official Symbol:
|NCBI Official Synonym Symbols:
|NCBI Protein Information:
|UniProt Protein Name:
|UniProt Synonym Protein Names:
|UniProt Gene Name:
|UniProt Entry Name: