Mouse IL36A 153 a.a. Recombinant Protein (RPPB0679)
- SKU:
- RPPB0679
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q9JLA2
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL36A 153 a.a. Recombinant Protein |
| Product Code: | RPPB0679 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL36A 153 a.a. |
| Synonyms: | Interleukin 36 alpha, FIL1E, IL1F6, FIL1, IL1(EPSILON), interleukin 1 family member 6 (epsilon), MGC129552, MGC129553. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2?m filtered concentrated solution in 1xPBS, pH 7.4 and 5% trehalose. |
| Solubility: | It is recommended to reconstitute the lyophilized IL36A 153 a.a. Mouse in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL36A 153 a.a. Mouse although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL36A 153 a.a. Mouse should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE and HPLC analyses. |
| Amino Acid Sequence: | RAASPSLRHV QDLSSRVWIL QNNILTAVPR KEQTVPVTIT LLPCQYLDTL ETNRGDPTYM GVQRPMSCLF CTKDGEQPVL QLGEGNIMEM YNKKEPVKAS LFYHKKSGTT STFESAAFPG WFIAVCSKGS CPLILTQELG EIFITDFEMI VVH |
| Biological Activity: | Fully biologically active when compared to standard. The ED50 as measured by its ability to induce IL-6 secretion in NIH-3T3 mouse embryonic fibroblast cells is less than 20ng/ml, corresponding to a specific activity of 50,000IU/mg. |
Murine IL-36a belongs to the IL-1 family that includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. Murine IL-36a is a 160 amino acid intracellular and secreted protein which holds no signal sequence, no prosegment and no potential N-linked glycosylation sites. IL-36a is released as a reaction to LPS and the cell ATP-induced activation of the P2X7 receptor. Mouse to human, full length IL-36a/IL-1F6 shares 54% aa sequence homology. IL-36a is mostly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine.
IL36A 153 a.a. Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 153 amino acids (8-160a.a.) and having a molecular mass of 17.0kDa.The IL36A 153 a.a. Mouse is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL1F6: Belongs to the IL-1 family.Protein type: CytokineCellular Component: extracellular region; extracellular spaceMolecular Function: cytokine activity; interleukin-1 receptor bindingBiological Process: cytokine and chemokine mediated signaling pathway; immune response; immune system process; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; positive regulation of cytokine production; positive regulation of interleukin-6 production |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9JLA2 |
| NCBI GenInfo Identifier: | 9506601 |
| NCBI Gene ID: | 54448 |
| NCBI Accession: | NP_062323.1 |
| UniProt Secondary Accession: | Q9JLA2 |
| UniProt Related Accession: | Q9JLA2 |
| Molecular Weight: | 18,015 Da |
| NCBI Full Name: | interleukin-36 alpha |
| NCBI Synonym Full Names: | interleukin 1 family, member 6 |
| NCBI Official Symbol: | Il1f6�� |
| NCBI Official Synonym Symbols: | Fil1; Il1f9; Il36a; IL-1H1; IL1RP2�� |
| NCBI Protein Information: | interleukin-36 alpha |
| UniProt Protein Name: | Interleukin-36 alpha |
| UniProt Synonym Protein Names: | FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 6; IL-1F6; Interleukin-1 homolog 1; IL-1H1 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il36a�� |
| UniProt Entry Name: | IL36A_MOUSE |
