Mouse IL36A Recombinant Protein (RPPB0680)
- SKU:
- RPPB0680
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q9JLA2
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL36A Recombinant Protein |
| Product Code: | RPPB0680 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | IL36A |
| Synonyms: | Interleukin-36 alpha, FIL1epsilon, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6,Interleukin-1 homolog 1, IL-1H1, Il36a, Fil1e, Il1e, Il1f6, Il1h1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | IL36A protein solution (1mg/ml) containing PhosphateBuffered Saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSMNKEKELRAASPSLRHV QDLSSRVWIL QNNILTAVPR KEQTVPVTIT LLPCQYLDTL ETNRGDPTYM GVQRPMSCLFCTKDGEQPVL QLGEGNIMEM YNKKEPVKAS LFYHKKSGTT STFESAAFPG WFIAVCSKGS CPLILTQELGEIFITDFEMI VVH |
Human IL-36a belongs to the IL-1 family which includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. IL-36a is an 18-22kDa, 158aa intracellular and secreted protein which holds no signal sequence, no prosegment and no potential from N-linked glycosylation sites. IL-36a is released as a reaction to LPS and the cell ATP-induced activation of the P2X7 receptor.Human IL-36a (aa 6-158) shares 57-68% aa sequence homology with mouse, rabbit, equine and bovine IL-36a and 27-57% aa sequence homology with other new IL-1 family members. IL-36a is mostly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine.
IL36A Mouse Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 183 amino acids (1-160 a.a) andhaving a molecular mass of 20.4kDa. IL36A is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL1F6: Belongs to the IL-1 family.Protein type: CytokineCellular Component: extracellular region; extracellular spaceMolecular Function: cytokine activity; interleukin-1 receptor bindingBiological Process: cytokine and chemokine mediated signaling pathway; immune response; immune system process; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; positive regulation of cytokine production; positive regulation of interleukin-6 production |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9JLA2 |
| NCBI GenInfo Identifier: | 9506601 |
| NCBI Gene ID: | 54448 |
| NCBI Accession: | NP_062323.1 |
| UniProt Secondary Accession: | Q9JLA2 |
| UniProt Related Accession: | Q9JLA2 |
| Molecular Weight: | 18,015 Da |
| NCBI Full Name: | interleukin-36 alpha |
| NCBI Synonym Full Names: | interleukin 1 family, member 6 |
| NCBI Official Symbol: | Il1f6�� |
| NCBI Official Synonym Symbols: | Fil1; Il1f9; Il36a; IL-1H1; IL1RP2�� |
| NCBI Protein Information: | interleukin-36 alpha |
| UniProt Protein Name: | Interleukin-36 alpha |
| UniProt Synonym Protein Names: | FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 6; IL-1F6; Interleukin-1 homolog 1; IL-1H1 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il36a�� |
| UniProt Entry Name: | IL36A_MOUSE |
