Mouse IL36B Recombinant Protein (RPPB0683)
- SKU:
- RPPB0683
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q9D6Z6
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL36B Recombinant Protein |
| Product Code: | RPPB0683 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL36B |
| Synonyms: | Interleukin 36 beta, interleukin 1 family member 8 (eta), Interleukin-1 homolog 2, IL1F8 (Canonical product IL-1F8a), IL-1F8 (FIL1-eta), Interleukin-1 Superfamily e, IL1H2, MGC126880, MGC126882. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized IL36B in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL36B Mouse although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL36B should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MMAFPPQSCV HVLPPKSIQM WEPNHNTMHG SSQSPRNYRV HDSQQMVWVL TGNTLTAVPA SNNVKPVILS LIACRDTEFQ DVKKGNLVFL GIKNRNLCFC CVEMEGKPTL QLKEVDIMNL YKERKAQKAF LFYHGIEGST SVFQSVLYPG WFIATSSIER QTIILTHQRG KLVNTNFYIE SEK |
| Biological Activity: | Measured by its binding ability in a functional ELISA to bind recombinant mouse IL-1 Rrp2. |
Mouse IL-36b belongs to the IL-1 family that includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). The IL-1 family members display a 12 b-strand, b-trefoil configuration, and are thought to have ascended from a mutual ancestral gene. Mouse IL-36b/IL-1F8 is a 183 amino acid protein which holds no signal sequence, no prosegment and no potential N-linked glycosylation site(s). Mouse IL-36b like its human homologue is actively secreted. Mouse IL-36k/IL-1F8 shares 61-74% aa homology with human IL-36k/IL-1F8 isoform 2 and rat IL-1F8.
IL36B Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids and having a molecular mass of 21.0kDa.The IL36B is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL36B: Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Belongs to the IL-1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: CytokineCellular Component: extracellular region; extracellular spaceMolecular Function: cytokine activity; interleukin-1 receptor bindingBiological Process: cytokine and chemokine mediated signaling pathway; immune response; immune system process; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; positive regulation of cytokine production; positive regulation of interleukin-6 production; positive regulation of T cell differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9D6Z6 |
| NCBI GenInfo Identifier: | 118601193 |
| NCBI Gene ID: | 69677 |
| NCBI Accession: | NP_081439.1 |
| UniProt Secondary Accession: | Q9D6Z6,Q8R461 |
| UniProt Related Accession: | Q9D6Z6 |
| Molecular Weight: | 20,878 Da |
| NCBI Full Name: | interleukin-36 beta |
| NCBI Synonym Full Names: | interleukin 1 family, member 8 |
| NCBI Official Symbol: | Il1f8�� |
| NCBI Official Synonym Symbols: | Il36b; 2310043N20Rik�� |
| NCBI Protein Information: | interleukin-36 beta |
| UniProt Protein Name: | Interleukin-36 beta |
| UniProt Synonym Protein Names: | Interleukin-1 family member 8; IL-1F8 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il36b�� |
| UniProt Entry Name: | IL36B_MOUSE |
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