Mouse PRDX2 Recombinant Protein (RPPB2177)
- SKU:
- RPPB2177
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q61171
- Research Area:
- Enzymes
Description
| Product Name: | Mouse PRDX2 Recombinant Protein |
| Product Code: | RPPB2177 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | PRDX2 |
| Synonyms: | PRDX2, Peroxiredoxin-2 (EC:1.11.1.15), TSA, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Thiol-specific antioxidant protein, Prdx2, Tdpx1, Tpx.�� |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | PRDX2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0) and 10% Glycerol 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMASGNA QIGKSAPDFT ATAVVDGAFK EIKLSDYRGK YVVLFFYPLD FTFVCPTEII AFSDHAEDFR KLGCEVLGVS VDSQFTHLAW INTPRKEGGL GPLNIPLLAD VTKSLSQNYG VLKNDEGIAY RGLFIIDAKG VLRQITVNDL PVGRSVDEAL RLVQAFQYTD EHGEVCPAGW KPGSDTIKPN VDDSKEYFSK HN |
| Biological Activity: | Specific activity is > 700 pmol/min/ug, Activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for minute.� |
PRDX2 is part of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. PRDX2 takes part as an antioxidant protective role in cells, and contributes to the antiviral activity of CD8(+) T-cells. PRDX2 has proliferative effect in cancer development or progression.�If PRDX2 protection is insufficient against peroxidases, the DNA damage results in neurological disease such as Alzheimer's or DNA damage leading to cancer.
PRDX2 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 222 amino acids (1-198 a.a) and having a molecular mass of 24.3kDa. PRDX2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q61171 |
| NCBI GenInfo Identifier: | 2499469 |
| NCBI Gene ID: | 21672 |
| NCBI Accession: | Q61171.3 |
| UniProt Secondary Accession: | Q61171,O88376, Q60796, Q9CWJ4, Q9DB49 |
| UniProt Related Accession: | Q61171 |
| Molecular Weight: | 21,779 Da |
| NCBI Full Name: | Peroxiredoxin-2 |
| NCBI Synonym Full Names: | peroxiredoxin 2 |
| NCBI Official Symbol: | Prdx2�� |
| NCBI Official Synonym Symbols: | TR; PRP; TPx; TSA; TDX1; NkefB; PrxII; TPx-B; Tdpx1; Torin; Band-8; AL022839�� |
| NCBI Protein Information: | peroxiredoxin-2 |
| UniProt Protein Name: | Peroxiredoxin-2 |
| UniProt Synonym Protein Names: | Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1 |
| Protein Family: | Peroxiredoxin |
| UniProt Gene Name: | Prdx2�� |
| UniProt Entry Name: |
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