Mouse SCGB1A1 Recombinant Protein (RPPB0899)
- SKU:
- RPPB0899
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q06318
- Research Area:
- Cytokines
Description
| Product Name: | Mouse SCGB1A1 Recombinant Protein |
| Product Code: | RPPB0899 |
| Size: | 50µg |
| Species: | Mouse |
| Target: | SCGB1A1 |
| Synonyms: | Uteroglobin, Clara cell 17 kDa protein, Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, PCB-binding protein, Secretoglobin family 1A member 1, Scgb1a1, Ugb, Utg, UG, CC16, CCSP, PCB-BP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The Uteroglobin protein was lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized SCGB1A1 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Uteroglobin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution SCGB1A1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | DICPGFLQVL EALLMESESG YVASLKPFNP GSDLQNAGTQ LKRLVDTLPQ ETRINIMKLT EKILTSPLCK QDLRF |
| Biological Activity: | The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0�g/ml, corresponding to a specific activity of > 200 IU/mg. |
Uteroglobin (SCGB1A1) which belongs to the Secretoglobin (SCGBs) superfamily, is a multifunctional protein that exerts anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. Uteroglobin is involved in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. SCGB1A1 is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia which communicate with the external environment. On top of sequestering pro-inflammatory mediators and carcinogens, Uteroglobin is implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. SCGB1A1 gene defects are associated with a susceptibility to asthma.
Uteroglobin Mouse Recombinant produced in E.coli is a non-glycosylated disulfide-linked homodimeric protein containing 2x75 amino acids chains and having a molecular mass of 16.7kDa.The SCGB1A1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Inhibitor; Cell cycle regulation Cellular Component: extracellular space; rough endoplasmic reticulum; endoplasmic reticulum; cytoplasm; extracellular region; nuclear envelope; intracellular; secretory granule Molecular Function:phospholipase A2 inhibitor activity Biological Process: negative regulation of interleukin-4 production; negative regulation of interleukin-13 production; negative regulation of T cell proliferation; response to cytokine stimulus; negative regulation of interferon-gamma production; regulation of inflammatory response; negative regulation of interleukin-5 production; negative regulation of transcription from RNA polymerase II promoter; regulation of mRNA stability; signal transduction |
| UniProt Code: | Q06318 |
| NCBI GenInfo Identifier: | 6755947 |
| NCBI Gene ID: | 22287 |
| NCBI Accession: | NP_035811.1 |
| UniProt Related Accession: | Q06318 |
| Molecular Weight: | |
| NCBI Full Name: | uteroglobin |
| NCBI Synonym Full Names: | secretoglobin, family 1A, member 1 (uteroglobin) |
| NCBI Official Symbol: | Scgb1a1�� |
| NCBI Official Synonym Symbols: | UG; UGB; Utg; CC10; CC16; CCSP; PCB-BP�� |
| NCBI Protein Information: | uteroglobin |
| UniProt Protein Name: | Uteroglobin |
| UniProt Synonym Protein Names: | Clara cell 17 kDa protein; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; PCB-binding protein; Secretoglobin family 1A member 1 |
| Protein Family: | Uteroglobin |
| UniProt Gene Name: | Scgb1a1�� |
| UniProt Entry Name: | UTER_MOUSE |
