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Anti-NME3 Antibody (CAB2774)

SKU:
CAB2774
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-NME3 Antibody CAB2774
  • Cell Death Antibodies 1 Anti-NME3 Antibody CAB2774
€139 - €419
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Description

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Antibody Name:Anti-NME3 Antibody
Antibody SKU:CAB2774
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-169 of human NME3 (NP_002504.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:THP-1, Raji, Mouse kidney, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-169 of human NME3 (NP_002504.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AHER TFLA VKPD GVQR RLVG EIVR RFER KGFK LVAL KLVQ ASEE LLRE HYAE LRER PFYG RLVK YMAS GPVV AMVW QGLD VVRT SRAL IGAT NPAD APPG TIRG DFCI EVGK NLIH GSDS VESA RREI ALWF RADE LLCW EDSA GHWL YE
Gene ID:4832
Uniprot:Q13232
Cellular Location:
Calculated MW:19kDa
Observed MW:19kDa
Synonyms:NME3, DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2
Background:
UniProt Protein Function:NME3: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis. Belongs to the NDK family.
UniProt Protein Details:

Protein type:Nucleotide Metabolism - pyrimidine; EC 2.7.4.6; Apoptosis; Nucleotide Metabolism - purine; Kinase, nucleoside diphosphate; Motility/polarity/chemotaxis; Kinase, other; Other group; NDK family

Chromosomal Location of Human Ortholog: 16q13.3

Cellular Component: mitochondrion; cytosol

Molecular Function:metal ion binding; nucleoside diphosphate kinase activity; ATP binding

Biological Process: GTP biosynthetic process; regulation of apoptosis; CTP biosynthetic process; pyrimidine nucleotide metabolic process; apoptosis; UTP biosynthetic process; nucleoside triphosphate biosynthetic process; nucleoside diphosphate phosphorylation; purine nucleotide metabolic process

UniProt Code:Q13232
NCBI GenInfo Identifier:21264477
NCBI Gene ID:4832
NCBI Accession:Q13232.2
UniProt Secondary Accession:Q13232,Q9BWH4,
UniProt Related Accession:Q13232
Molecular Weight:19,015 Da
NCBI Full Name:Nucleoside diphosphate kinase 3
NCBI Synonym Full Names:NME/NM23 nucleoside diphosphate kinase 3
NCBI Official Symbol:NME3  
NCBI Official Synonym Symbols:NDPKC; NDPK-C; NM23H3; DR-nm23; NM23-H3; c371H6.2  
NCBI Protein Information:nucleoside diphosphate kinase 3; NDK 3; NDP kinase 3; NDP kinase C; non-metastatic cells 3, protein expressed in; nucleoside diphosphate kinase C
UniProt Protein Name:Nucleoside diphosphate kinase 3
UniProt Synonym Protein Names:DR-nm23; Nucleoside diphosphate kinase C; NDPKC; nm23-H3
Protein Family:Nucleoside diphosphate kinase
UniProt Gene Name:NME3  
UniProt Entry Name:NDK3_HUMAN
Anti-NME3 Antibody (CAB2774)Western blot analysis of extracts of various cell lines, using NME3 antibody (CAB2774) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-NME3 Antibody (CAB2774)Immunohistochemistry of paraffin-embedded human stomach using NME3 antibody (CAB2774) at dilution of 1:100 (40x lens).

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