Notch1 Rabbit Polyclonal Antibody (CAB18282)
- SKU:
- CAB18282
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
Product Name: | Notch1 Rabbit Polyclonal Antibody |
SKU: | CAB18282 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1567-1729 of human Notch1 (NP_060087.3). |
Sequence: | ERLA AGTL VVVV LMPP EQLR NSSF HFLR ELSR VLHT NVVF KRDA HGQQ MIFP YYGR EEEL RKHP IKRA AEGW AAPD ALLG QVKA SLLP GGSE GGRR RREL DPMD VRGS IVYL EIDN RQCV QASS QCFQ SATD VAAF LGAL ASLG SLNI PYKI EAVQ SETV EPP |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | hN1; AOS5; TAN1; AOVD1; Notch1 |
Positive Sample: | Jurkat |
Cellular Localization: | Cell membrane, Nucleus, Single-pass type I membrane protein. |
Calculated MW: | 273kDa |
Observed MW: | 120kDa |
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Purification Method: | Affinity purification |
Gene ID: | 4851 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |