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Anti-Phospho-INSR-Y1146/IGF1R-Y1131 pAb Antibody (CABP0863)

SKU:
CABP0863
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€329 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Phospho-INSR-Y1146/IGF1R-Y1131 Antibody
Antibody SKU:CABP0863
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around Y1146 of human INSR and Y1131 of human IGF1R.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T, HeLa
Immunogen:A synthetic phosphorylated peptide around Y1146 of human INSR and Y1131 of human IGF1R.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3643/3480
Uniprot:P06213/P08069
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:155kDa
Observed MW:95kDa
Anti-Phospho-INSR-Y1146/IGF1R-Y1131 pAb (CABP0863)Western blot analysis of extracts of various cell lines, using Phospho-INSR-Y1146/IGF1R-Y1131 Rabbit pAb (CABP0863) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Synonyms:INSR/IGF1R
Background:This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

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