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Anti-PRKCQ Antibody (CAB5834)

SKU:
CAB5834
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-PRKCQ Antibody CAB5834
  • Immunology Antibodies 2 Anti-PRKCQ Antibody CAB5834
€139 - €419
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Description

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Antibody Name:Anti-PRKCQ Antibody
Antibody SKU:CAB5834
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PRKCQ (NP_006248.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PRKCQ (NP_006248.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSPF LRIG LSNF DCGS CQSC QGEA VNPY CAVL VKEY VESE NGQM YIQK KPTM YPPW DSTF DAHI NKGR VMQI IVKG KNVD LISE TTVE LYSL AERC RKNN GKTE IWLE LKPQ GRML MNAR YFLE MSDT KDMN EFET EGFF ALHQ RRGA IKQA KVHH VKCH EFTA TFFP QPTF CSVC HEFV WGLN KQGY QCRQ CNAA IHKK CIDK VIAK CTGS AINS RETM FHKE RFKI DM
Gene ID:5588
Uniprot:Q04759
Cellular Location:Cell membrane, Cytoplasm, Peripheral membrane protein
Calculated MW:67kDa/74kDa/81kDa
Observed MW:82kDa
Synonyms:PRKCQ, PRKCT, nPKC-theta
Background:Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
UniProt Protein Function:PKCT: an AGC kinase of the PKC family. A novel PKC: Ca2+ independent but still regulated by PS, DAG and phorbol esters. Contains 2 zinc-dependent phorbol-ester and DAG binding domains. Expressed in skeletal muscle and hematopoietic cells. May play a role in T cell receptor signaling and insulin resistance. Required for TCR-induced NF-kappaB activation in mature T lymphocytes.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; PKC family; Delta subfamily

Chromosomal Location of Human Ortholog: 10p15

Cellular Component: plasma membrane; immunological synapse; cytosol

Molecular Function:protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; ubiquitin-protein ligase activity; ATP binding

Biological Process: positive regulation of interleukin-17 production; axon guidance; phototransduction, visible light; platelet activation; apoptosis; positive regulation of interleukin-2 biosynthetic process; membrane protein ectodomain proteolysis; negative regulation of insulin receptor signaling pathway; protein ubiquitination; protein amino acid phosphorylation; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; rhodopsin mediated signaling; positive regulation of interleukin-4 production; regulation of rhodopsin mediated signaling; regulation of transcription, DNA-dependent; innate immune response; positive regulation of T cell proliferation; regulation of cell growth; positive regulation of T cell activation; inflammatory response; blood coagulation; cell structure disassembly during apoptosis

NCBI Summary:Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
UniProt Code:Q04759
NCBI GenInfo Identifier:334848126
NCBI Gene ID:5588
NCBI Accession:NP_001229342.1
UniProt Secondary Accession:Q04759,Q14DH6, Q3MJF1, Q64FY5, Q9H508, Q9H549,
UniProt Related Accession:Q04759
Molecular Weight:81,865 Da
NCBI Full Name:protein kinase C theta type isoform 2
NCBI Synonym Full Names:protein kinase C, theta
NCBI Official Symbol:PRKCQ  
NCBI Official Synonym Symbols:PRKCT; nPKC-theta  
NCBI Protein Information:protein kinase C theta type
UniProt Protein Name:Protein kinase C theta type
UniProt Synonym Protein Names:nPKC-theta
UniProt Gene Name:PRKCQ  
UniProt Entry Name:KPCT_HUMAN
Anti-PRKCQ Antibody (CAB5834)Western blot analysis of extracts of various cell lines, using PRKCQ Antibody (CAB5834) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-PRKCQ Antibody (CAB5834)Immunohistochemistry of paraffin-embedded human esophageal cancer using PRKCQ antibody (CAB5834) at dilution of 1:200 (40x lens).

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