FAK Rabbit Monoclonal Antibody (CAB11131)
- SKU:
- CAB11131
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| Product Name: | FAK Rabbit Monoclonal Antibody |
| SKU: | CAB11131 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FAK (Q05397). |
| Sequence: | TVSW DSGG SDEA PPKP SRPG YPSP RSSE GFYP SPQH MVQT NHYQ VSGY PGSH GITA MAGS IYPG QASL LDQT DSWN HRPQ EIAM WQPN VEDS TVLD LRGI G |
| Tested Applications: | WB IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
| Synonyms: | FAK; FADK; FAK1; FRNK; FADK 1; PPP1R71; p125FAK; pp125FAK |
| Positive Sample: | MCF7,Mouse brain,Rat brain |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein, cell cortex, centrosome, cytoskeleton, focal adhesion, microtubule organizing center. |
| Calculated MW: | 119kDa |
| Observed MW: | 125kDa |
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
| Purification Method: | Affinity purification |
| Gene ID: | 5747 |
| Clone Number: | ARC0171 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using FAK pAb (CAB11131) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s. |
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