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Anti-PTN Antibody (CAB3124)

SKU:
CAB3124
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 8 Anti-PTN Antibody CAB3124
  • Cell Biology Antibodies 8 Anti-PTN Antibody CAB3124
€139 - €419
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Description

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Antibody Name:Anti-PTN Antibody
Antibody SKU:CAB3124
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic Peptide of human PTN
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:SH-SY5Y, Mouse eye, Mouse brain
Immunogen:A synthetic Peptide of human PTN
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5764
Uniprot:P21246
Cellular Location:Secreted
Calculated MW:18kDa
Observed MW:17kDa
Synonyms:PTN, HARP, HB-GAM, HBBM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, OSF-1
Background:
UniProt Protein Function:PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: extracellular space; endoplasmic reticulum

Molecular Function:heparin binding; growth factor activity; protein phosphatase inhibitor activity

Biological Process: nervous system development; positive regulation of cell division; negative regulation of catalytic activity; positive regulation of cell proliferation; learning; transmembrane receptor protein tyrosine phosphatase signaling pathway; bone mineralization

UniProt Code:P21246
NCBI GenInfo Identifier:131553
NCBI Gene ID:5764
NCBI Accession:P21246.1
UniProt Secondary Accession:P21246,Q5U0B0, Q6ICQ5, Q9UCC6,
UniProt Related Accession:P21246
Molecular Weight:18,942 Da
NCBI Full Name:Pleiotrophin
NCBI Synonym Full Names:pleiotrophin
NCBI Official Symbol:PTN  
NCBI Official Synonym Symbols:HARP; HBNF; HBGF8; NEGF1  
NCBI Protein Information:pleiotrophin; HBBM; OSF-1; HB-GAM; HBGF-8; HBNF-1; osteoblast-specific factor 1; heparin-binding brain mitogen; heparin binding growth factor 8; heparin-binding growth factor 8; heparin affin regulatory protein; neurite growth-promoting factor 1; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth-promoting factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
UniProt Protein Name:Pleiotrophin
UniProt Synonym Protein Names:Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1; OSF-1
Protein Family:Pleiotrophin
UniProt Gene Name:PTN  
UniProt Entry Name:PTN_HUMAN
Anti-PTN Antibody (CAB3124)Western blot analysis of extracts of various cell lines, using PTN antibody (CAB3124) at 1:400 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s.
Anti-PTN Antibody (CAB3124)Immunohistochemistry of paraffin-embedded mouse testis using PTN Antibody (CAB3124) at dilution of 1:100 (40x lens).

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