Rat GMF B Recombinant Protein (RPPB0365)
- SKU:
- RPPB0365
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- Q63228
- Research Area:
- Neurotrophins
Description
| Product Name: | Rat GMF B Recombinant Protein |
| Product Code: | RPPB0365 |
| Size: | 10µg |
| Species: | Rat |
| Target: | GMF B |
| Synonyms: | Glia maturation factor beta, GMFB, GMF-B, GMF-beta, GMF, C79176, AI851627, D14Ertd630e, 3110001H22Rik, 3110001O16Rik. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated (1.0mg/ml) solution in 1�PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized GMFB in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GMFB although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution GMFB should be stored at 4C between 2-7 days and for future use below -18C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | SESLVVCDVA EDLVEKLRKF RFRKETHNAA IIMKIDKDKR LVVLDEELEG VSPDELKDEL PERQPRFIVY SYKYQHDDGR VSYPLCFIFS SPLGCKPEQQ MMYAGSKNKL VQTAELTKVF EIRNTEDLTE EWLREKLGFF H |
GMFB is part of the GMF subfamily of the larger actin-binding protein ADF family. GMFB is phosphorylated after phorbol ester stimulation, and is crucial for the nervous system. GMFB causes brain cell differentiation, stimulates neural regeneration and inhibits tumor cell proliferation. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.
Glia Maturation Factor-Beta (GMF-Beta) Rat Recombinant produced in E.Coli is a signle, non-glycosylated, polypeptide chain containing 141 amino acids and having a total molecular mass of 16.6kDa. GMF-Beta is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GMF-beta: This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. Belongs to the actin-binding proteins ADF family. GMF subfamily. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis; Inhibitor Cellular Component: intracellular Molecular Function:growth factor activity; actin binding Biological Process: locomotory behavior; learning |
| NCBI Summary: | transcription factor; may be important for brain cell development [RGD, Feb 2006] |
| UniProt Code: | Q63228 |
| NCBI GenInfo Identifier: | 13624295 |
| NCBI Gene ID: | 81661 |
| NCBI Accession: | NP_112294.1 |
| UniProt Related Accession: | Q63228 |
| Molecular Weight: | 16,736 Da |
| NCBI Full Name: | glia maturation factor beta |
| NCBI Synonym Full Names: | glia maturation factor, beta |
| NCBI Official Symbol: | Gmfb�� |
| NCBI Protein Information: | glia maturation factor beta |
| UniProt Protein Name: | Glia maturation factor beta |
| Protein Family: | Glia maturation factor |
| UniProt Gene Name: | Gmfb�� |
| UniProt Entry Name: | GMFB_RAT |
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