Rat IL 13 109 a.a. Recombinant Protein (RPPB0579)
- SKU:
- RPPB0579
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P42203
- Research Area:
- Cytokines
Description
| Product Name: | Rat IL 13 109 a.a. Recombinant Protein |
| Product Code: | RPPB0579 |
| Size: | 10µg |
| Species: | Rat |
| Target: | IL 13 109 a.a. |
| Synonyms: | NC300, ALRH, BHR1, P600, IL-13. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein (1mg/ml) was lyophilized in PBS, pH7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin 13 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-13 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL13 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | VRRSTSPPVA LRELIEELSN ITQDQKTSLC NSSIVWSVDI TAGGFCAALE SLTNISSCNA IHRTQRILNG LCNQKASDVA SSPPDTKIEV AQFISKLLNY SKQLFRYGH |
| Biological Activity: | ED50 range = 40ng/ml, corresponding to a specific activity of > 25,000IU/mg as determined by the dose dependent proliferation of human TF-1 cells. Optimal concentration for individual application should be determined by a dose response assay. |
IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Interleukin-13 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 109 amino acids and having a molecular mass of 11.9 kDa. The IL-13 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane Molecular Function:interleukin-13 receptor binding; cytokine activity Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; microglial cell activation; regulation of proton transport; positive regulation of mast cell degranulation; response to lipopolysaccharide; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; response to ethanol; positive regulation of protein secretion; response to mechanical stimulus; positive regulation of B cell proliferation; immune response; positive regulation of ion transport; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of NAD(P)H oxidase activity; inflammatory response; positive regulation of macrophage activation |
| NCBI Summary: | cytokine; involved in inflammatory and immune responses [RGD, Feb 2006] |
| UniProt Code: | P42203 |
| NCBI GenInfo Identifier: | 1170528 |
| NCBI Gene ID: | 116553 |
| NCBI Accession: | P42203.1 |
| UniProt Related Accession: | P42203 |
| Molecular Weight: | 14,093 Da |
| NCBI Full Name: | Interleukin-13 |
| NCBI Synonym Full Names: | interleukin 13 |
| NCBI Official Symbol: | Il13�� |
| NCBI Protein Information: | interleukin-13; IL-13; T-cell activation protein P600 |
| UniProt Protein Name: | Interleukin-13 |
| UniProt Synonym Protein Names: | T-cell activation protein P600 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il13�� |
| UniProt Entry Name: | IL13_RAT |
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