Rat IL 2 Recombinant Protein (RPPB0483)
- SKU:
- RPPB0483
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P17108
- Research Area:
- Cytokines
Description
| Product Name: | Rat IL 2 Recombinant Protein |
| Product Code: | RPPB0483 |
| Size: | 20µg |
| Species: | Rat |
| Target: | IL 2 |
| Synonyms: | T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The IL-2 solution contains 0.2�m filtered solution in 20mM PB pH3.5 and 30% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by SDS-PAGE and HPLC. |
| Amino Acid Sequence: | APTSSPAKET QQHLEQLLLD LQVLLRGIDN YKNLKLPMML TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL EDAGNFISNI RVTVVKLKGS ENKFECQFDD EPATVVEFLR RWIAICQSII STMTQ |
| Biological Activity: | The ED50 as determined by the dose-dependant stimulation of murine CTLL-2 cells is less than 0.2ng/ml, corresponding to a Specific Activity of 5,000,000IU/mg. |
IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Interleukin-2 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 135 amino acids and having a molecular mass of 16kDa.The IL-2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. |
| NCBI Summary: | cytokine produced by T-cells in response to antigen or mitogen stimulation [RGD, Feb 2006] |
| UniProt Code: | P17108 |
| NCBI GenInfo Identifier: | 124328 |
| NCBI Gene ID: | 116562 |
| NCBI Accession: | P17108.1 |
| UniProt Related Accession: | P17108 |
| Molecular Weight: | 17,633 Da |
| NCBI Full Name: | Interleukin-2 |
| NCBI Synonym Full Names: | interleukin 2 |
| NCBI Official Symbol: | Il2�� |
| NCBI Protein Information: | interleukin-2; IL-2; TCGF; T-cell growth factor |
| UniProt Protein Name: | Interleukin-2 |
| UniProt Synonym Protein Names: | T-cell growth factor; TCGF |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il2�� |
| UniProt Entry Name: | IL2_RAT |
