Rat Resistin Recombinant Protein (RPPB0933)
- SKU:
- RPPB0933
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- Q8K4J7
- Research Area:
- Cytokines
Description
| Product Name: | Rat Resistin Recombinant Protein |
| Product Code: | RPPB0933 |
| Size: | 25µg |
| Species: | Rat |
| Target: | Resistin |
| Synonyms: | Cysteine-rich secreted protein FIZZ3, Adipose tissue-specific secretory factor, ADSF, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, RSTN, XCP1, RETN1, MGC126603, MGC126609. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Filtered (0.4�m) and lyophilized from 0.5mg/ml in 20mM Tris pH 8.0. |
| Solubility: | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASHMPSMS LCPMDEAISK KINQDFSSLL PAAMKNTVLH CWSVSSRGRL ASCPEGTTVT SCSCGSGCGS WDVREDTMCH CQCGSIDWTA ARCCTLRVGS |
Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins (monomeric peptide contains 11 cysteine residues) referred to as the RELM family, and is also described as ADSF (Adipose Tissue-Specific Secretory Factor) or FIZZ3 (Found in Inflammatory Zone 3). Mouse resistin is expressed as a 114 amino acid prepeptide; its hydrofobic Nterminal 20 amino acid signal peptide is cleaved before its secretion. Mouse resistin circulates in blood as a homodimeric protein consisting of two 94 amino acid polypeptides, which are disulfide-linked via Cys26.Resistin may be an important link between obesity. Mouse resistin, specifically produced and secreted by adipocyte, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity. Steppan et al. have suggested that resistin suppressed the ability to stimulate glucose uptake. They have also suggested that resistin was present at elevated levels in blood of obese mice, and was down regulated by fasting and by antidiabetic drugs. Way et al., on the other hand, have found that resistin expression is severely suppressed in obesity.Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. In contrast, the human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression.
Resistin Rat Recombinant is manufactured with N-terminal fusion of His tag. Resistin Rat Recombinant His-Tagged Fusion Protein is an 11.9 kDa protein containing 94 amino acid residues of the Resistin Rat and 16 additional amino acid residues � His Tag (underlined).
| NCBI Summary: | may contribute to impaired glucose tolerance and inhibition of adipocyte differentiation [RGD, Feb 2006] |
| UniProt Code: | Q8K4J7 |
| NCBI GenInfo Identifier: | 21426805 |
| NCBI Gene ID: | 246250 |
| NCBI Accession: | NP_653342.1 |
| Molecular Weight: | |
| NCBI Full Name: | resistin |
| NCBI Synonym Full Names: | resistin |
| NCBI Official Symbol: | Retn�� |
| NCBI Protein Information: | resistin |
| UniProt Protein Name: | Protein Retn |
| UniProt Synonym Protein Names: | Protein Retn |
| Protein Family: | Resistin |
| UniProt Gene Name: | Retn�� |
| UniProt Entry Name: | Q8K4J7_RAT |
