RC3H2 Antibody (PACO41946)
- SKU:
- PACO41946
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | RC3H2 Antibody (PACO41946) |
| Antibody SKU: | PACO41946 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Roquin-2 protein (251-506AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5. |
| Synonyms: | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid, binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2), RC3H2, MNAB RNF164 |
| UniProt Protein Function: | MNAB: 6 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating system; DNA-bindingChromosomal Location of Human Ortholog: 9q34Cellular Component: cell surface; cytoplasm; membrane; nucleoplasmMolecular Function: DNA binding; ligase activity; mRNA binding; ubiquitin-protein ligase activity; zinc ion bindingBiological Process: alveolus development; B cell homeostasis; limb development; lymph node development; multicellular organism growth; post-embryonic development; protein polyubiquitination; spleen development; T cell homeostasis; T cell proliferation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9HBD1 |
| NCBI GenInfo Identifier: | 156105697 |
| NCBI Gene ID: | 54542 |
| NCBI Accession: | NP_001094058.1 |
| UniProt Secondary Accession: | Q9HBD1,Q4VXB1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2 Q9HBD2, Q9NWN9, Q9NXE1 |
| UniProt Related Accession: | Q9HBD1 |
| Molecular Weight: | 96,362 Da |
| NCBI Full Name: | roquin-2 isoform 1 |
| NCBI Synonym Full Names: | ring finger and CCCH-type domains 2 |
| NCBI Official Symbol: | RC3H2Â Â |
| NCBI Official Synonym Symbols: | MNAB; RNF164Â Â |
| NCBI Protein Information: | roquin-2 |
| UniProt Protein Name: | Roquin-2 |
| UniProt Synonym Protein Names: | Membrane-associated nucleic acid-binding protein; RING finger and CCCH-type zinc finger domain-containing protein 2; RING finger protein 164 |
| Protein Family: | Roquin |
| UniProt Gene Name: | RC3H2Â Â |
| UniProt Entry Name: | RC3H2_HUMAN |