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Recombinant Cofilin Monoclonal Antibody (RMEA0743)

Datasheet MSDS
SKU RMEA0743
Product Type Antibody
Reactivity Human, Mouse, Rat
Applications WB, IHC, IF, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C110740
Conjugate Unconjugated
€409 - €559

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Description

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Recombinant Cofilin Monoclonal Antibody

The Recombinant Cofilin Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110740) against Cofilin. The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB, IHC, IF and ELISA applications. It has been validated by WB analysis of C6 and IHC analysis of Human breast carcinoma. The target is localized to the nucleus matrix, cytoplasm, cytoskeleton, cell projection, ruffle membrane, peripheral membrane protein, cytoplasmic side, cell projection, lamellipodium membrane, peripheral membrane protein, cytoplasmic side, cell projection, lamellipodium, cell projection, growth cone, cell projection, axon, Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

Product Name:Recombinant Cofilin Monoclonal Antibody
SKU:RMEA0743
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:18 kDa phosphoprotein, CFL, CFL 1, CFL1, COF, COF1, cofilin, Cofilin 1, Cofilin 1 non muscle, Cofilin non muscle isoform, cofilin-1, epididymis secretory protein Li, epididymis secretory protein Li 15, HEL-S, HEL-S-15, N-Cofilin, non-muscle isoform, p18
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant Human Cofilin protein
Applications:WBIHCIFELISA
Clonality:Recombinant Monoclonal
Clone No:C110740
Host:Rabbit
Isotype:Rabbit IgG
Target:Cofilin
Conjugation:Unconjugated
Observed MW:19 kDa
Calculated MW:19 kDa
Recommended Dilution:IHC 1:20000-50000; WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000
UniProt:P23528
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Product ImageImmunohistochemistry of paraffin-embedded human breast carcinoma using Recombinant Cofilin Monoclonal Antibody at dilution of 1:200.
Product ImageWestern Blot with Recombinant Cofilin Monoclonal Antibody at dilution of 1:1000 dilution. Lane A: C6 lysate. Observed-MW:19 kDa Calculated-MW:19 kDa
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