Angiogenin belongs to the ribonuclease family of enzymes. Angiogenin is largely found in the liver. It may function as a tRNA-specific ribonuclease that hydrolyzes cellular tRNAs, thereby inhibiting protein synthesis. Angiogenin is a potent inducer of new blood vessel formation. Angiogenin binds to actin on the surface of endothelial cells and is endocytosed and translocated to the nucleus. In vivo, RNH1 regulates angiogenic activity via interactions. Angiogenin is also connected to amyotrophic lateral sclerosis (ALS), which is a progressive disease of motor neurons in the cortex, brain stem and spinal cord. Human Angiogenin/ANG Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Angiogenin/ANG Recombinant Protein (RPES2481)
Product Code:
RPES2481
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Angiogenin, Ribonuclease 5, RNase 5, ANG, RNASE5
Accession:
P03950
Sequence:
Gln25-Pro147
Fusion tag:
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Angiogenin is produced by our E.coli expression system and the target gene encoding Gln25-Pro147 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
14.3 kDa
AP Mol Mass:
14 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
