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Anti-Serotonin transporter Antibody (CAB19110)

SKU:
CAB19110
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Neuroscience
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-Serotonin transporter Antibody
Antibody SKU:CAB19110
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Serotonin transporter
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:Human serum, A-549, HT-29, Rat brain
Immunogen:A synthesized peptide derived from human Serotonin transporter
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6532
Uniprot:P31645
Cellular Location:
Calculated MW:70kDa
Observed MW:70kDa
Anti-Serotonin transporter Antibody (CAB19110)Western blot - Serotonin transporter Rabbit mAb (CAB19110)
Synonyms:5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, SLC6A4
Background:This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
UniProt Protein Function:SERT: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; endomembrane system; endosome membrane; cytosol; lipid raft

Molecular Function:actin filament binding; serotonin transmembrane transporter activity; protein binding; protein homodimerization activity; myosin binding; serotonin:sodium symporter activity; cocaine binding; syntaxin-1 binding; monoamine transmembrane transporter activity; nitric-oxide synthase binding; Rab GTPase binding

Biological Process: circadian rhythm; response to drug; vasoconstriction; response to toxin; monoamine transport; positive regulation of cell cycle; social behavior; thalamus development; serotonin uptake; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; protein oligomerization; memory; response to estradiol stimulus; negative regulation of granule cell precursor proliferation; negative regulation of neuron differentiation; brain morphogenesis; response to hypoxia; sperm ejaculation; serotonin transport; transmembrane transport; protein homooligomerization; response to nutrient

Disease: Anxiety; Obsessive-compulsive Disorder

NCBI Summary:This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
UniProt Code:P31645
NCBI GenInfo Identifier:400630
NCBI Gene ID:6532
NCBI Accession:P31645.1
UniProt Secondary Accession:P31645,Q5EE02,
UniProt Related Accession:P31645,AAB26687
Molecular Weight:74,979 Da
NCBI Full Name:Sodium-dependent serotonin transporter
NCBI Synonym Full Names:solute carrier family 6 (neurotransmitter transporter), member 4
NCBI Official Symbol:SLC6A4  
NCBI Official Synonym Symbols:HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR  
NCBI Protein Information:sodium-dependent serotonin transporter; 5HT transporter; serotonin transporter 1; Na+/Cl- dependent serotonin transporter; 5-hydroxytryptamine (serotonin) transporter; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
UniProt Protein Name:Sodium-dependent serotonin transporter
UniProt Synonym Protein Names:5HT transporter; 5HTT; Solute carrier family 6 member 4
UniProt Gene Name:SLC6A4  
UniProt Entry Name:SC6A4_HUMAN

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