UniProt Protein Function: | SLC11A1: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. Belongs to the NRAMP family.Protein type: Cell surface; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Vesicle; TransporterChromosomal Location of Human Ortholog: 2q35Cellular Component: late endosome; late endosome membrane; lysosome; phagocytic vesicle membrane; plasma membraneMolecular Function: manganese ion transmembrane transporter activity; metal ion:hydrogen antiporter activity; protein homodimerization activity; transition metal ion transmembrane transporter activityBiological Process: activation of protein kinase activity; antigen processing and presentation of peptide antigen; cell redox homeostasis; cellular cadmium ion homeostasis; cellular iron ion homeostasis; defense response to bacterium; defense response to Gram-negative bacterium; defense response to protozoan; inflammatory response; interleukin-2 production; interleukin-3 production; iron ion homeostasis; iron ion transport; L-arginine import; macrophage activation; manganese ion transport; MHC class II biosynthetic process; mRNA stabilization; negative regulation of cytokine production; nitrite transport; phagocytosis; positive regulation of cytokine production; positive regulation of dendritic cell antigen processing and presentation; positive regulation of interferon-gamma production; positive regulation of phagocytosis; positive regulation of T-helper 1 type immune response; positive regulation of transcription from RNA polymerase II promoter; respiratory burst; response to bacterium; response to lipopolysaccharide; T cell cytokine production; T cell proliferation during immune response; vacuolar acidification; wound healingDisease: Buruli Ulcer, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To |
UniProt Protein Details: | |
NCBI Summary: | This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49279 |
NCBI GenInfo Identifier: | 1352521 |
NCBI Gene ID: | 6556 |
NCBI Accession: | P49279.1 |
UniProt Secondary Accession: | P49279,C0H5Y3 |
UniProt Related Accession: | P49279 |
Molecular Weight: | 47,292 Da |
NCBI Full Name: | Natural resistance-associated macrophage protein 1 |
NCBI Synonym Full Names: | solute carrier family 11 member 1 |
NCBI Official Symbol: | SLC11A1Â Â |
NCBI Official Synonym Symbols: | LSH; NRAMP; NRAMP1Â Â |
NCBI Protein Information: | natural resistance-associated macrophage protein 1 |
UniProt Protein Name: | Natural resistance-associated macrophage protein 1 |
UniProt Synonym Protein Names: | Solute carrier family 11 member 1 |
Protein Family: | Natural resistance-associated macrophage protein |
UniProt Gene Name: | SLC11A1Â Â |
UniProt Entry Name: | NRAM1_HUMAN |