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Immunohistochemistry analysis of paraffin-embedded human colon using TNF-α Rabbit mAb (CAB21265) at dilution of 1:1000(40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with IHC staining protocol.
Key Features

TNF-alpha Monoclonal Antibody (CAB21265)

Datasheet MSDS
SKU CAB21265
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Rabbit
Synonyms DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha, TNF-α
€131 - €457

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Description

system_update_altDatasheetsystem_update_altMSDS

TNF-alpha Monoclonal Antibody (CAB21265)

The TNF-alpha Monoclonal Antibody (CAB21265) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody, derived from mouse hybridoma cells, is highly specific for TNF and has been validated for use in various experimental applications, including ELISA, immunohistochemistry, and flow cytometry.TNF is a cytokine that plays a critical role in inflammation and the regulation of immune cells. Dysregulation of TNF signaling has been implicated in numerous diseases, including autoimmune disorders, inflammatory conditions, and cancer.

This antibody is validated for use in IHC-P, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:TNF-alpha Monoclonal Antibody
SKU:CAB21265
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC52538
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:VRSS SRTP SDKP VAHV VANP QAEG QLQW LNRR ANAL LANG VELR DNQL VVPS EGLY LIYS QVLF KGQG CPST HVLL THTI SRIA VSYQ TKVN LLSA IKSP CQRE TPEG AEAK PWYE PIYL GGVF QLEK GDRL SAEI NRPD YLDF AESG QVYF GIIA L
Tested Applications:IHC-P ELISA
Recommended Dilution:
IHC-P1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha, TNF-α
Cellular Localization:Membrane, Secreted.
Calculated MW:26kDa

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Purification MethodAffinity purification
Gene ID7124
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human colon using TNF-α Rabbit mAb (CAB21265) at dilution of 1:1000 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human liver cancer using TNF-α Rabbit mAb (CAB21265) at dilution of 1:1000 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
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