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Anti-TP53INP1 Antibody (CAB8274)

SKU:
CAB8274
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
€139 - €419
Frequently bought together:

Description

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Antibody Name:TP53INP1 Rabbit Polyclonal Antibody
Antibody SKU:CAB8274
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TP53INP1 (NP_001129205.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse spleen, Mouse lung
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TP53INP1 (NP_001129205.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFQR LNKM FVGE VSSS SNQE PEFN EKED DEWI LVDF IDTC TGFS AEEE EEEE DISE ESPT EHPS VFSC LPAS LECL ADTS DSCF LQFE SCPM EESW FITP
Gene ID:94241
Uniprot:Q96A56
Cellular Location:Cytoplasm, Cytoplasmic vesicle, Nucleus, PML body, autophagosome, cytosol
Calculated MW:18kDa/27kDa
Observed MW:32kDa
Synonyms:TP53INP1, SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1
Background:
UniProt Protein Function:TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; Tumor suppressor; Cell cycle regulation

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: PML body; autophagic vacuole; cytoplasmic vesicle; nucleus; cytosol

Molecular Function:antioxidant activity; protein binding

Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; response to heat; apoptosis; positive regulation of transcription, DNA-dependent; autophagic cell death; response to stress; cell cycle arrest; negative regulation of cell migration; positive regulation of autophagy; autophagic vacuole formation

UniProt Code:Q96A56
NCBI GenInfo Identifier:209180469
NCBI Gene ID:94241
NCBI Accession:NP_001129205.1
UniProt Secondary Accession:Q96A56,Q969R9, B2RCE5,
UniProt Related Accession:Q96A56
Molecular Weight:27,366 Da
NCBI Full Name:tumor protein p53-inducible nuclear protein 1 isoform b
NCBI Synonym Full Names:tumor protein p53 inducible nuclear protein 1
NCBI Official Symbol:TP53INP1  
NCBI Official Synonym Symbols:SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B  
NCBI Protein Information:tumor protein p53-inducible nuclear protein 1; p53-inducible p53DINP1; stress-induced protein; p53-dependent damage-inducible nuclear protein 1
UniProt Protein Name:Tumor protein p53-inducible nuclear protein 1
UniProt Synonym Protein Names:Stress-induced protein; p53-dependent damage-inducible nuclear protein 1
Protein Family:Tumor protein p53-inducible nuclear protein
UniProt Gene Name:TP53INP1  
UniProt Entry Name:T53I1_HUMAN
Anti-TP53INP1 Polyclonal Antibody (CAB8274)Western blot analysis of extracts of various cell lines, using TP53INP1 antibody (CAB8274) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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