null

Anti-Tyrosine Hydroxylase Antibody (CAB5079)

SKU:
CAB5079
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DYT14
DYT5b
TYH
Research Area:
Metabolism
  • Metabolism Antibodies 3 Anti-Tyrosine Hydroxylase Antibody CAB5079
  • Metabolism Antibodies 3 Anti-Tyrosine Hydroxylase Antibody CAB5079
€139 - €419
Frequently bought together:

Description

Product Name:Tyrosine Hydroxylase Rabbit mAb
Product Code:CAB5079
Size:20uL, 50uL, 100uL
Synonyms:DYT14, DYT5b, TYH
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Tyrosine Hydroxylase
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human Tyrosine Hydroxylase
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7054
Uniprot:P07101
Calculated MW:59kDa
Observed MW:59KDa
UniProt Protein Function:TH: an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described.
UniProt Protein Details:

Protein type:EC 1.14.16.2; Vesicle; Endoplasmic reticulum; Mitochondrial; Amino Acid Metabolism - tyrosine; Oxidoreductase

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: synaptic vesicle; internal side of plasma membrane; neuron projection; smooth endoplasmic reticulum; mitochondrion; dendrite; melanosome membrane; cytoplasm; terminal button; perikaryon; cytoplasmic vesicle; cytosol; nucleus

Molecular Function:amino acid binding; protein domain specific binding; protein binding; enzyme binding; ferric iron binding; ferrous iron binding; dopamine binding; oxygen binding; tyrosine 3-monooxygenase activity

Biological Process: heart morphogenesis; heart development; response to lipopolysaccharide; dopamine biosynthetic process; phytoalexin metabolic process; norepinephrine biosynthetic process; dopamine biosynthetic process from tyrosine; catecholamine biosynthetic process; response to electrical stimulus; epinephrine biosynthetic process; neurotransmitter biosynthetic process; response to pyrethroid; response to corticosterone stimulus; response to light stimulus; anatomical structure morphogenesis; phthalate metabolic process; mating behavior; social behavior; eye photoreceptor cell development; organ morphogenesis; circadian sleep/wake cycle; response to ethanol; response to zinc ion; cerebral cortex development; response to activity; response to water deprivation; synaptic transmission, dopaminergic; response to peptide hormone stimulus; locomotory behavior; fatty acid metabolic process; response to salt stress; regulation of heart contraction; response to estradiol stimulus; sensory perception of sound; visual perception; glycoside metabolic process; response to nutrient levels; terpene metabolic process; sphingolipid metabolic process; eating behavior; response to amphetamine; multicellular organismal aging; isoquinoline alkaloid metabolic process; response to herbicide; learning; response to ether; memory; synaptic vesicle amine transport; pigmentation; response to hypoxia; embryonic camera-type eye morphogenesis

Disease: Segawa Syndrome, Autosomal Recessive

NCBI Summary:The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P07101
NCBI GenInfo Identifier:239938945
NCBI Gene ID:7054
NCBI Accession:P07101.5
UniProt Secondary Accession:P07101,Q0PWM2, Q0PWM3, Q15585, Q15588, Q15589, Q2M3B4 B7ZL70, B7ZL73,
UniProt Related Accession:P07101
Molecular Weight:528
NCBI Full Name:Tyrosine 3-monooxygenase
NCBI Synonym Full Names:tyrosine hydroxylase
NCBI Official Symbol:TH  
NCBI Official Synonym Symbols:TYH; DYT14; DYT5b  
NCBI Protein Information:tyrosine 3-monooxygenase; dystonia 14; tyrosine 3-hydroxylase
UniProt Protein Name:Tyrosine 3-monooxygenase
UniProt Synonym Protein Names:Tyrosine 3-hydroxylase; TH
UniProt Gene Name:TH  
UniProt Entry Name:TY3H_HUMAN

Related Products