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ABCA4 Rabbit Polyclonal Antibody (CAB10556)

SKU:
CAB10556
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 1 Anti-ABCA4 Antibody CAB10556
  • Signal Transduction Antibodies 1 Anti-ABCA4 Antibody CAB10556
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ABCA4 Rabbit Polyclonal Antibody
SKU:CAB10556
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-300 of human ABCA4 (NP_000341.2).
Sequence:QELL MNAP ESQH LGRI WTEL HILS QFMD TLRT HPER IAGR GIRI RDIL KDEE TLTL FLIK NIGL SDSV VYLL INSQ VRPE QFAH GVPD LALK DIAC SEAL LERF IIFS QRRG AKTV RYAL CSLS QGTL QWIE DTLY ANVD FFKL FRVL PTLL DSRS QGIN LRSW GGIL SDMS PRIQ EFIH RPSM QDLL WVT
Tested Applications:WB ELISA
Recommended Dilution:WB,1:100 - 1:500
Synonyms:FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1; ABCA4
Positive Sample:Mouse eye
Conjugate:Unconjugated
Cellular Localization:Membrane, Multi-pass membrane protein.
Calculated MW:256kDa
Observed MW:256kDa

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, and the gene product mediates transport of an essental molecule, all-trans-retinal aldehyde (atRAL), across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Purification Method:Affinity purification
Gene ID:24
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse eye, using ABCA4 Rabbit pAb (CAB10556) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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