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ABL1 Rabbit Polyclonal Antibody (CAB0282)

SKU:
CAB0282
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-ABL1 Antibody CAB0282
  • Cell Death Antibodies 1 Anti-ABL1 Antibody CAB0282
  • Cell Death Antibodies 1 Anti-ABL1 Antibody CAB0282
  • Cell Death Antibodies 1 Anti-ABL1 Antibody CAB0282
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:ABL1 Rabbit Polyclonal Antibody
SKU:CAB0282
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1130 of human c-Abl (NP_005148.2).
Sequence:TAFI PLIS TRVS LRKT RQPP ERIA SGAI TKGV VLDS TEAL CLAI SRNS EQMA SHSA VLEA GKNL YTFC VSYV DSIQ QMRN KFAF REAI NKLE NNLR ELQI CPAT AGSG PAAT QDFS KLLS SVKE ISDI VQR
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl; c-Abl
Positive Sample:Rat liver
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Lipid-anchor, Mitochondrion, Nucleus, Nucleus membrane, cytoskeleton.
Calculated MW:123kDa
Observed MW:150kDa

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Purification Method:Affinity purification
Gene ID:25
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Rat liver, using c-Abl Rabbit pAb (CAB0282) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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