Anti-Alpha B Crystallin Antibody

Alpha B Crystallin Antibody

Alpha B Crystallin Antibody is a rabbit polyclonal antibody directed against Alpha B Crystallin, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse, Rat, Bovine and Chicken. Purified by Affinity.

Alpha B Crystallin (CRYAB) is a small heat shock protein (sHSP) originally identified as a structural component of the vertebrate eye lens. While it contributes to lens transparency by preventing protein aggregation, CRYAB is now recognized for its broader role as a molecular chaperone and cytoprotective agent in various tissues, including the central nervous system. CRYAB shares structural and functional similarities with other sHSPs such as HSP25 and HSP27. It binds to misfolded or denatured proteins, stabilizing them in a soluble state and preventing toxic aggregation—a key pathological feature in neurodegenerative diseases like Alzheimer’s, Parkinson’s, and multiple sclerosis. Under cellular stress, CRYAB becomes phosphorylated, enhancing its chaperone activity and contributing to protein quality control. Unlike its Alpha A counterpart, Alpha B Crystallin is widely expressed beyond the lens, including in glial cells, neurons, and muscle tissue. It interacts with diverse cellular components such as membrane proteins, cytoskeletal elements, nuclear proteins, and DNA, supporting its role in maintaining intracellular architecture and stress resilience. Importantly, CRYAB is overexpressed in several neurological disorders and has been shown to inhibit apoptosis by blocking caspase activation. This anti-apoptotic function positions CRYAB as a promising therapeutic target and biomarker in neurodegenerative disease research, with potential applications in neuroprotection, inflammation modulation, and regenerative medicine. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 200 µl. For research use only; not for diagnostic or therapeutic procedures.