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Alkaline Phosphatase (ALPL) Rabbit Polyclonal Antibody (CAB12396)

SKU:
CAB12396
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 1 Anti-ALPL Antibody CAB12396
  • Signal Transduction Antibodies 1 Anti-ALPL Antibody CAB12396
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Alkaline Phosphatase (ALPL) Rabbit Polyclonal Antibody
SKU:CAB12396
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 230-440 of human Alkaline Phosphatase (ALPL) (NP_000469.3).
Sequence:NKTD VEYE SDEK ARGT RLDG LDLV DTWK SFKP RYKH SHFI WNRT ELLT LDPH NVDY LLGL FEPG DMQY ELNR NNVT DPSL SEMV VVAI QILR KNPK GFFL LVEG GRID HGHH EGKA KQAL HEAV EMDR AIGQ AGSL TSSE DTLT VVTA DHSH VFTF GGYT PRGN SIFG LAPM LSDT DKKP FTAI LYGN GPGY KVVG GERE NVSM VDYA HNN
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:HOPS; HPPA; HPPC; HPPI; HPPO; TNAP; TNALP; APTNAP; TNSALP; AP-TNAP; TNS-ALP; Alkaline Phosphatase (ALPL)
Positive Sample:HeLa
Conjugate:Unconjugated
Cellular Localization:Cell membrane, GPI-anchor, Lipid-anchor.
Calculated MW:57kDa
Observed MW:80kDa

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.

Purification Method:Affinity purification
Gene ID:249
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HeLa cells, using Alkaline Phosphatase (ALPL) Rabbit pAb (CAB12396) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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