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4-1BBL/CD137L Rabbit Monoclonal Antibody (CAB3386)

SKU:
CAB3386
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
4-1BB-L
CD137L
TNLG5A
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:4-1BBL/CD137L Rabbit Monoclonal Antibody
SKU:CAB3386
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 155-254 of human 4-1BBL/CD137L (P41273).
Sequence:GEGS GSVS LALH LQPL RSAA GAAA LALT VDLP PASS EARN SAFG FQGR LLHL SAGQ RLGV HLHT EARA RHAW QLTQ GATV LGLF RVTP EIPA GLPS PRSE
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:CD137L; TNLG5A; 4-1BB-L; 4-1BBL/CD137L
Positive Sample:HeLa,Raji,SH-SY5Y,Mouse lung,Mouse brain,Rat lung
Conjugate:Unconjugated
Cellular Localization:Membrane, Single-pass type II membrane protein.
Calculated MW:27kDa
Observed MW:27kDa

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Purification Method:Affinity purification
Gene ID:8744
Clone Number:ARC1963
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using 4-1BBL/CD137L Rabbit mAb (CAB3386) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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