The Anti-CD40 Antibody (CAB20214) is a high-quality monoclonal antibody designed for research involving the CD40 cell surface receptor. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.CD40 is a critical molecule involved in immune activation and regulation, specifically in the activation of B cells and the immune response to pathogens. The Anti-CD40 Antibody binds specifically to the CD40 protein, allowing for the detection and analysis of CD40 expression in different cell types.
This antibody is ideal for studies in immunology, cancer research, and autoimmune disorders where CD40 signaling plays a significant role.Understanding the role of CD40 in immune responses is essential for developing targeted therapies for diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. The Anti-CD40 Antibody provides researchers with a valuable tool for investigating the complex interactions involving the CD40 receptor and its implications in disease pathology.
Product Name:
CD40 Rabbit Monoclonal Antibody
SKU:
CAB20214
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-193 of human CD40 (P25942).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
31kDa
Observed MW:
Refer to figures
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
958
Clone Number:
ARC5133-01
Storage Buffer:
Store at 4℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% thimerosal,pH7.3.
Flow cytometric analysis of CD40 Rabbit mAb Cocotail (1:100 dilution) in Daudi cells (Orange) compare to rabbit IgG Isotype control (Blue) and non-staining control (Red ).
