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Anti-CR2/CD21 Antibody (CAB1267)

SKU:
CAB1267
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
C3DR
CD21
CR
CVID7
SLEB9
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

Product Name:CR2/CD21 Rabbit mAb
Product Code:CAB1267
Size:20uL, 50uL, 100uL
Synonyms:C3DR, CD21, CR, CVID7, SLEB9
Applications:WB, IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CR2/CD21
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:Jurkat
Immunogen:A synthesized peptide derived from human CR2/CD21
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1380
Uniprot:P20023
Calculated MW:155kDa
Observed MW:155KDa
UniProt Protein Function:CR2: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7). A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Belongs to the receptors of complement activation (RCA) family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: receptor complex

Molecular Function:complement binding; DNA binding; protein homodimerization activity

Biological Process: B cell differentiation; B cell proliferation

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 7; Systemic Lupus Erythematosus, Susceptibility To, 9

NCBI Summary:This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:P20023
NCBI GenInfo Identifier:215273962
NCBI Gene ID:1380
NCBI Accession:P20023.2
UniProt Secondary Accession:P20023,Q13866, Q14212, Q53EL2, Q5BKT9, Q5SR46, Q5SR48 C9JHD2,
UniProt Related Accession:P20023
Molecular Weight:
NCBI Full Name:Complement receptor type 2
NCBI Synonym Full Names:complement component 3d receptor 2
NCBI Official Symbol:CR2  
NCBI Official Synonym Symbols:CR; C3DR; CD21; CVID7; SLEB9  
NCBI Protein Information:complement receptor type 2
UniProt Protein Name:Complement receptor type 2
UniProt Synonym Protein Names:Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD_antigen: CD21
Protein Family:Complement receptor
UniProt Gene Name:CR2  
UniProt Entry Name:CR2_HUMAN

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