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Anti-Fetuin A/AHSG Antibody (CAB19264)

SKU:
CAB19264
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
AHSG
A2HS
AHS
FETUA
HSGA
alpha-2-HS-glycoprotein
$167 - $503
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Description

Product Name:Fetuin A/AHSG Rabbit mAb
Product Code:CAB19264
Size:20uL, 50uL, 100uL
Synonyms:AHSG, A2HS, AHS, FETUA, HSGA, alpha-2-HS-glycoprotein
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human Fetuin A/AHSG.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Human plasma
Immunogen:Recombinant protein of human Fetuin A/AHSG.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:197
Uniprot:P02765
Cellular Location:Secreted
Calculated MW:58kDa
Observed MW:50KDa
UniProt Protein Function:FETUA: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space; extracellular region

Molecular Function:kinase inhibitor activity; cysteine protease inhibitor activity

Biological Process: negative regulation of bone mineralization; pinocytosis; ossification; positive regulation of phagocytosis; regulation of inflammatory response; acute-phase response; negative regulation of phosphorylation; negative regulation of insulin receptor signaling pathway; skeletal development; regulation of bone mineralization

NCBI Summary:Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]
UniProt Code:P02765
NCBI GenInfo Identifier:112910
NCBI Gene ID:197
NCBI Accession:P02765.1
UniProt Secondary Accession:P02765,O14961, O14962, Q9P152, A8K9N6, B2R7G1,
UniProt Related Accession:P02765,AAB29984
Molecular Weight:39,325 Da
NCBI Full Name:Alpha-2-HS-glycoprotein
NCBI Synonym Full Names:alpha-2-HS-glycoprotein
NCBI Official Symbol:AHSG  
NCBI Official Synonym Symbols:AHS; A2HS; HSGA; FETUA  
NCBI Protein Information:alpha-2-HS-glycoprotein; fetuin-A; alpha-2-Z-globulin; ba-alpha-2-glycoprotein
UniProt Protein Name:Alpha-2-HS-glycoprotein
UniProt Synonym Protein Names:Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-ACleaved into the following 2 chains:Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B
Protein Family:Alpha-2-HS-glycoprotein
UniProt Gene Name:AHSG  
UniProt Entry Name:FETUA_HUMAN

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