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GABA A Receptor beta 1 (GABRB1) Rabbit Monoclonal Antibody (CAB19681)

Datasheet MSDS
SKU CAB19681
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human, Mouse, Rat
Host Species Rabbit
Synonyms DEE45, EIEE45, GABA A Receptor beta 1 (GABRB1)
€131 - €457

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Description

system_update_altDatasheetsystem_update_altMSDS

GABA A Receptor beta 1 (GABRB1) Monoclonal Antibody (CAB19681)

The GABA A Receptor beta 1 (GABRB1) Monoclonal Antibody (CAB19681) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody, raised in rabbits, has been rigorously tested and validated for use in Western blot applications, specifically targeting the GABRB1 protein.GABA-A receptors are the major inhibitory neurotransmitter receptors in the central nervous system and play a crucial role in regulating neuronal excitability. Dysfunction of these receptors has been implicated in various neurological disorders such as epilepsy, anxiety, and insomnia. The GABRB1 subunit is an essential component of the GABA-A receptor complex, and understanding its expression and function is essential for elucidating the molecular mechanisms underlying these conditions.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:GABA A Receptor beta 1 (GABRB1) Monoclonal Antibody
SKU:CAB19681
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Clone Number:ARC2229
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:EKNK LEMN KVQV DAHG NILL STLE IRNE TSGS EVLT SVSD PKAT MYSY DSAS IQYR KPLS SREA YGRA LDRH GVPS KGRI RRRA SQLK VKIP DLTD VNSI D
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DEE45, EIEE45, GABA A Receptor beta 1 (GABRB1)
Positive Sample:SH-SY5Y, Mouse spinal cord, Mouse brain, Rat brain
Cellular Localization:Cytoplasm, Dendrite, Gaba-Ergic Synapse, Neuron Projection, Nuclear Envelope, Plasma Membrane, Postsynaptic Specialization Membrane, Presynaptic Active Zone Membrane, Schaffer Collateral - Ca1 Synapse, Synapse.
Calculated MW:54kDa
Observed MW:54kDa

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.

Purification MethodAffinity purification
Gene ID2560
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using GABA A Receptor beta 1 (GABRB1) (GABRB1) Rabbit mAb (CAB19681) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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