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Anti-gamma-Tubulin Antibody (CAB9657)

SKU:
CAB9657
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CDCBM4
GCP-1
TUBG
TUBGCP1
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:?-Tubulin Rabbit mAb
Product Code:CAB9657
Size:20uL, 50uL, 100uL
Synonyms:CDCBM4, GCP-1, TUBG, TUBGCP1
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ?-Tubulin
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U2OS, MCF7, NIH/3T3, Jurkat, Mouse brain, Rat testis, Rat brain
Immunogen:A synthesized peptide derived from human ?-Tubulin
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7283
Uniprot:P23258
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:48kDa
Observed MW:49kDa
UniProt Protein Function:TUBG1: Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Interacts with GCP2 and GCP3. Interacts with B9D2. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO/C1orf88. Belongs to the tubulin family.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: centriole; centrosome; pericentriolar material; recycling endosome; condensed nuclear chromosome; apical part of cell; cytoplasmic microtubule; nonmotile primary cilium; cytoplasm; leading edge; polar microtubule; cytosol; gamma-tubulin complex

Molecular Function:GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: metabolic process; organelle organization and biogenesis; microtubule cytoskeleton organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule nucleation; meiotic spindle organization and biogenesis; cytoplasmic microtubule organization and biogenesis

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 4

NCBI Summary:This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
UniProt Code:P23258
NCBI GenInfo Identifier:20455518
NCBI Gene ID:7283
NCBI Accession:P23258.2
UniProt Secondary Accession:P23258,Q53X79, Q9BW59,
UniProt Related Accession:P23258
Molecular Weight:451
NCBI Full Name:Tubulin gamma-1 chain
NCBI Synonym Full Names:tubulin, gamma 1
NCBI Official Symbol:TUBG1  
NCBI Official Synonym Symbols:TUBG; GCP-1; CDCBM4; TUBGCP1  
NCBI Protein Information:tubulin gamma-1 chain; tubulin, gamma polypeptide; gamma-tubulin complex component 1
UniProt Protein Name:Tubulin gamma-1 chain
UniProt Synonym Protein Names:Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1
UniProt Gene Name:TUBG1  
UniProt Entry Name:TBG1_HUMAN

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