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Anti-HLA-DMB Antibody (CAB0948)

SKU:
CAB0948
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HLA-DMB
D6S221E
RING7
major histocompatibility complex
class II
DM beta
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

Product Name:HLA-DMB Rabbit mAb
Product Code:CAB0948
Size:20uL, 50uL, 100uL
Synonyms:HLA-DMB, D6S221E, RING7, major histocompatibility complex, class II, DM beta
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human HLA-DMB.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-29, Raji
Immunogen:A synthesized peptide derived from human HLA-DMB.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3109
Uniprot:P28068
Cellular Location:Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein
Calculated MW:29kDa
Observed MW:29KDa
UniProt Protein Function:HLA-DMB: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Belongs to the MHC class II family.
UniProt Protein Details:

Protein type:Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: lysosomal membrane; late endosome membrane; integral to membrane; MHC class II protein complex

Biological Process: peptide antigen assembly with MHC class II protein complex; antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of T cell proliferation; immune response; MHC class II protein complex assembly

NCBI Summary:HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
UniProt Code:P28068
NCBI GenInfo Identifier:133160
NCBI Gene ID:3109
NCBI Accession:P28068.1
UniProt Related Accession:P28068
Molecular Weight:
NCBI Full Name:HLA class II histocompatibility antigen, DM beta chain
NCBI Synonym Full Names:major histocompatibility complex, class II, DM beta
NCBI Official Symbol:HLA-DMB  
NCBI Official Synonym Symbols:RING7; D6S221E  
NCBI Protein Information:HLA class II histocompatibility antigen, DM beta chain
UniProt Protein Name:HLA class II histocompatibility antigen, DM beta chain
UniProt Synonym Protein Names:MHC class II antigen DMB; Really interesting new gene 7 protein
Protein Family:HLA class II histocompatibility antigen
UniProt Gene Name:HLA-DMB  
UniProt Entry Name:DMB_HUMAN

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