Anti-Human CASP3 Recombinant Nanobody (VHH2) is a recombinant nanobody targeting Human CASP3 (clone VHH2). Format: VHH-8His-Cys-tag (alpaca host). Reactivity: Human. Supplied as a liquid in 0.01M PBS, pH 7.4. Applications: ELISA. Purity: >95% as determined by SDS-PAGE. For research use only.
Caspase-3 (CASP3) is a ~31 kDa protein. Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis. Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively).
Product Name:
Anti-Human CASP3 Recombinant Nanobody (VHH2)
Size:
50 µg, 100 µg, 1 mg
Product SKU:
GXRM04003
Target:
Caspase-3
Host Species:
Alpaca
Antibody Type:
Monoclonal
Clone ID:
VHH2
Reactivity:
Human
Buffer:
0.01M PBS pH 7.4
Storage & Shipping:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Format:
Liquid
Applications:
ELISA
Recommended Dilutions:
ELISA: 1:2000-1:20000
Antibody Isotype:
VHH-8His-Cys-tag
Purity:
>95% as determined by SDS-PAGE.
Purification:
Protein A/G purified from cell culture supernatant.
