Anti-Human CD33 Recombinant Nanobody (SAA2052) is a recombinant nanobody targeting Human CD33 (clone SAA2052). Format: VHH-8His-Cys-tag (alpaca host). Reactivity: Human, Cynomolgus. Supplied as a liquid in 0.01M PBS, pH 7.4. Applications: ELISA and flow cytometry. Purity: >95% as determined by SDS-PAGE. For research use only.
Myeloid cell surface antigen CD33 is a ~39 kDa protein. Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. CD33 is the therapeutic target of gemtuzumab ozogamicin (Mylotarg).
Product Name:
Anti-Human CD33 Recombinant Nanobody (SAA2052)
Size:
50 µg, 100 µg, 1 mg
Product SKU:
GXRM03594
Target:
Myeloid cell surface antigen CD33
Host Species:
Alpaca
Antibody Type:
Monoclonal
Clone ID:
SAA2052
Reactivity:
Human, Monkey
Buffer:
0.01M PBS pH 7.4
Storage & Shipping:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
